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Fig. 5 | BMC Genomics

Fig. 5

From: Impact of blood collection and processing on peripheral blood gene expression profiling in type 1 diabetes

Fig. 5

Differentially expressed genes in the peripheral blood of established T1D patients. a Heatmap showing the hierarchical clustering of samples based on genes that were found by microarray analysis to be differentially expressed by ≥2-fold in established TN-T1D patients compared to healthy controls (Moderated T-test, Benjamini-Hochberg correction, P < 0.05). Both TN-T1D and control samples were collected and processed in Tempus tubes. b Venn-diagram showing that 316 genes out of the 901 genes that are affected by sample processing are also differentially expressed in the peripheral blood of established T1D patients. The two sets of genes listed below were further examined by QPCR (in blue) and NanoString arrays (see Fig. 5). c QPCR data for select genes that are differentially expressed in TN-T1D patients compared to healthy controls (Tempus controls, n = 9; TN-T1D, n = 10; *P < 0.05, two-tailed unpaired Mann-Whitney test)

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BMC Genomics

ISSN: 1471-2164

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