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Table 4 Positively selected sites across carnivorous TLRs as inferred by different methods

From: Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus)

Locus Size (aa) -2lnΔL PAML M8 FEL REL Total No. of sites Sites located in LRRs ω
TLR1 789 11.57** 629 69, 289, 291, 316, 629 289, 291, 316, 324, 326, 366, 395, 561, 629 10 8 0.527
TLR2 766 5.88 None 557, 609 487, 557, 609 3 1 0.348
TLR3 905 2.02 None 13, 270, 293 13, 69, 270, 279, 293, 344, 587 7 6 0.307
TLR4 833 7.24* 193, 295, 341 46, 193, 319, 562, 564 46, 58, 91, 139, 193, 295, 306, 308, 319, 321, 339, 341, 347, 364, 369, 384, 393, 394, 464, 505, 510, 514, 517, 562, 564, 620, 832 27 24 0.493
TLR5 858 1.60 None 63, 137, 609 None 3 2 0.252
TLR6 797 2.34 None 109, 631 None 2 1 0.491
TLR7 1050 N.A. None None None - - 0.173
TLR8 1038 2.42 None 234, 457, 683, 689 202, 234, 390, 416, 457, 683, 689 7 7 0.226
TLR9 1032 10.70** 5 5, 457, 627 None 3 2 0.163
TLR10 807 N.A. None None None - - 0.439
  1. Positively selected codons inferred by more than one ML method are underlined. The overall ω for each TLR was calculated by the SLAC method. N.A. indicates not available because of a low -2lnΔL value. *p < 0.05, **p < 0.01