Table 2 Candidate genes that are differentially expressed in T21 placentas
From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21
Chr. | Up regulation | Down regulation | ||||
|---|---|---|---|---|---|---|
No. | (%) | Gene symbol | No. | (%) | Gene symbol | |
1 | 6 | 7.8 | ATP1A4, C1orf106, INADL, KIF26B, MCOLN3, SYTL1 | 3 | 9.1 | HEYL, NBPF8, WLS |
2 | 3 | 3.9 | FZD5, OBSL1, ZNF514 | 1 | 3.0 | PXDN |
3 | 1 | 1.3 | ZNF717 | 5 | 15.2 | ADAMTS9, GOLIM4, NCEH1, PAQR9, RICKLE2 |
4 | 2 | 2.6 | ANKRD37, FRAS1 | 3 | 9.1 | AGA, C4orf32, SLC7A11 |
5 | 0 | 0.0 | - | 2 | 6.1 | F2RL1, TICAM2 |
6 | 0 | 0.0 | - | 2 | 6.1 | CDKAL1, MAP3K5 |
7 | 3 | 3.9 | DLX6-AS1, LEP, MET | 1 | 3.0 | HGF |
9 | 1 | 1.3 | STXBP1 | 1 | 3.0 | LAMC3 |
10 | 1 | 1.3 | CPXM2 | 2 | 6.1 | MMRN2, MRPL43 |
11 | 1 | 1.3 | MPZL3 | 2 | 6.1 | JAM3, NRGN |
12 | 2 | 2.6 | MBD6, OLR1 | 2 | 6.1 | MMP19, PHLDA1 |
13 | 2 | 2.6 | FLT1, METTL21C | 1 | 3.0 | EFNB2 |
15 | 1 | 1.3 | CAPN3 | 1 | 3.0 | ANPEP |
16 | 2 | 2.6 | MYLK3, PDXDC1 | 1 | 3.0 | LITAF |
17 | 2 | 2.6 | KSR1, WSB1 | 1 | 3.0 | GJC1 |
19 | 3 | 3.9 | RDH13, ZNF331, ZNF614 | 0 | 0.0 | - |
21 | 46 | 59.7 | ADAMTS1, ADAMTS5, AGPAT3, APP, ATP5J, ATP5O, BACE2, BACH1, BRWD1, BTG3, C21orf33, C21orf91, C2CD2, CCT8, CRYZL1, CSTB, DONSON, DYRK1A, ETS2, GABPA, GART, GCFC1, HSPA13, HUNK, IGSF5, LTN1, MCM3AP, MIS18A, MORC3, MRPL39, NDUFV3, NRIP1, PCP4, PSMG1, PTTG1IP, SCAF4, SETD4, SLC37A1, SON, SYNJ1, TRAPPC10, TTC3, U2AF1, UBE2G2, USP16, USP25 | 0 | 0.0 | - |
22 | 1 | 1.3 | H1F0 | 2 | 6.1 | KDELR3, SUSD2 |
X | 0 | 0.0 | - | 3 | 9.1 | COL4A5, GPC4, GPRASP2 |
Total | 77 | 100.0 | 33 | 100.0 | ||