Skip to main content

Table 2 Candidate genes that are differentially expressed in T21 placentas

From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21

Chr. Up regulation Down regulation
No. (%) Gene symbol No. (%) Gene symbol
1 6 7.8 ATP1A4, C1orf106, INADL, KIF26B, MCOLN3, SYTL1 3 9.1 HEYL, NBPF8, WLS
2 3 3.9 FZD5, OBSL1, ZNF514 1 3.0 PXDN
3 1 1.3 ZNF717 5 15.2 ADAMTS9, GOLIM4, NCEH1, PAQR9, RICKLE2
4 2 2.6 ANKRD37, FRAS1 3 9.1 AGA, C4orf32, SLC7A11
5 0 0.0 - 2 6.1 F2RL1, TICAM2
6 0 0.0 - 2 6.1 CDKAL1, MAP3K5
7 3 3.9 DLX6-AS1, LEP, MET 1 3.0 HGF
9 1 1.3 STXBP1 1 3.0 LAMC3
10 1 1.3 CPXM2 2 6.1 MMRN2, MRPL43
11 1 1.3 MPZL3 2 6.1 JAM3, NRGN
12 2 2.6 MBD6, OLR1 2 6.1 MMP19, PHLDA1
13 2 2.6 FLT1, METTL21C 1 3.0 EFNB2
15 1 1.3 CAPN3 1 3.0 ANPEP
16 2 2.6 MYLK3, PDXDC1 1 3.0 LITAF
17 2 2.6 KSR1, WSB1 1 3.0 GJC1
19 3 3.9 RDH13, ZNF331, ZNF614 0 0.0 -
21 46 59.7 ADAMTS1, ADAMTS5, AGPAT3, APP, ATP5J, ATP5O, BACE2, BACH1, BRWD1, BTG3, C21orf33, C21orf91, C2CD2, CCT8, CRYZL1, CSTB, DONSON, DYRK1A, ETS2, GABPA, GART, GCFC1, HSPA13, HUNK, IGSF5, LTN1, MCM3AP, MIS18A, MORC3, MRPL39, NDUFV3, NRIP1, PCP4, PSMG1, PTTG1IP, SCAF4, SETD4, SLC37A1, SON, SYNJ1, TRAPPC10, TTC3, U2AF1, UBE2G2, USP16, USP25 0 0.0 -
22 1 1.3 H1F0 2 6.1 KDELR3, SUSD2
X 0 0.0 - 3 9.1 COL4A5, GPC4, GPRASP2
Total 77 100.0   33 100.0  
  1. Chr chromosome, No number, T21 trisomy 21