Table 4 GO analysis of candidate genes
From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21
Pathway | Gene symbol | rawP | adjP | ||
|---|---|---|---|---|---|
Up regulation in T21 | Down regulation in T21 | ||||
Whole genome | |||||
BP | Hydrogen peroxide-mediated programmed cell death | MET | HGF, MAP3K5 | 2.65e-07 | 2.01e-04 |
Ovulation from ovarian follicle | ADAMTS1, LEP, NRIP1 | MMP19 | 7.94e-07 | 4.00e-04 | |
Negative regulation of hydrogen peroxide-mediated programmed cell death | MET | HGF | 4.17e-05 | 7.60e-03 | |
Striated muscle cell differentiation | APP, CAPN3, MET, MYLK3,OBSL1 | COL4A5, EFNB2 | 4.00e-04 | 4.54e-02 | |
MF | Arginine/serine domain binding | SON, U2AF1 | - | 8.00e-04 | 4.21e-02 |
Peptidase activity | ADAMTS1, ADAMTS5, BACE2, CAPN3, CPXM2, USP16, USP25 | ADAMTS9, ANPEP, HGF, MMP19 | 8.00e-04 | 4.21e-02 | |
Metallopeptidase activity | ADAMTS1, ADAMTS5, CPXM2 | ADAMTS9, ANPEP, MMP19 | 1.00e-03 | 4.21e-02 | |
Glucocorticoid receptor binding | ETS2, NRIP1 | - | 1.40e-03 | 4.28e-02 | |
CC | Extracellular matrix | ADAMTS1,ADAMTS5, CPXM2, FRAS1, | ADAMTS9, COL4A5, GPC4, LAMC3, MMP19, MMRN2, PXDN | 3.64e-05 | 4.70e-04 |
Mitochondrial proton-transporting ATP synthase complex, coupling factor | ATP5J, ATP5O | - | 1.20e-03 | 4.61e-02 | |
Extracellular region part | ADAMTS1, ADAMTS5, CPXM2, FLT1, LEP, MET | ADAMTS9, PXDN, COL4A5, GPC4, HGF, JAM3, LAMC3, MMP19, MMRN2 | 1.60e-03 | 4.61e-02 | |
Basement membrane | ADAMTS1 | COL4A5, LAMC3, MMRN2 | 1.80e-03 | 4.61e-02 | |
Chromosomes other than HSA21 | |||||
BP | Hydrogen peroxide-mediated programmed cell death | MET | HGF, MAP3K5 | 4.75e-08 | 3.28e-05 |
Anatomical structure formation involved in morphogenesis | CAPN3, FLT1, FZD5, KIF26B, MET, MYLK3, OBSL1, STXBP1 | ANPEP, COL4A5, EFNB2, GJC1, HEYL, HGF, JAM3, MMP19, MMRN2, WLS, | 8.78e-06 | 2.30e-03 | |
Regulation of intracellular protein kinase cascade | CAPN3,FLT1, FZD5, LEP, MET | F2RL1, HGF, LITAF, MAP3K5, TICAM2, WLS, | 3.23e-05 | 3.70e-03 | |
Cell differentiation | CAPN3,FLT1, FZD5, MCOLN3, MET, MYLK3, LEP, OBSL1, STXBP1 | ADAMTS9, ANPEP, COL4A5, EFNB2, F2RL1, GJC1, HEYL, HGF, JAM3, LAMC3, MMP19, PRICKLE2, SLC7A11 | 9.31e-05 | 4.90e-03 | |
Circulatory system development | FLT1, FZD5, GJC1, JAM3, MYLK3, OBSL1 | ANPEP, EFNB2, HEYL, MMP19, MMRN2 | 7.93e-05 | 4.90e-03 | |
CC | Proteinaceous extracellular matrix | - | ADAMTS9, COL4A5, GPC4, LAMC, MMP19, MMRN2, PXDN | 2.00e-04 | 5.90e-03 |
Extracellular space | CPXM2, FLT1, JAM3, LEP, MET, | ADAMTS9, GPC4, HGF, MMRN2, PXDN | 5.00e-04 | 1.11e-02 | |