Table 6 Disease association of candidate genes
From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21
Disease | Gene symbol | rawP | adjP |
|---|---|---|---|
Whole genome | |||
Up-regulated genes in trisomy 21 | |||
Trisomy21 | APP, ATP5O, BACE2, BACH1, BRWD1, BTG3, C2CD2, C21orf33, CRYZL1, DONSON, DYRK1A, ETS2, GART, GCFC1, NDUFV3, MCM3AP, MIS18A, PCP4, PSMG1, SETD4, SON, TTC3, UBE2G2,USP25 | 6.04e-34 | 5.80e-32 |
Chromosome disorders | APP, BACE2, BACH1, BRWD1, C2CD2, C21orf33, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, SYNJ1, TRAPPC10, TTC3, UBE2G2, USP25 | 3.83e-20 | 1.84e-18 |
Mental retardation | APP, BACE2, BACH1, BRWD1, C2CD2, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, STXBP1, TTC3, UBE2G2, USP25 | 4.89e-17 | 1.56e-15 |
Neurobehavioral manifestations | APP, BACE2, BACH1, BRWD1, C2CD2, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, SON, TTC3,UBE2G2, USP25 | 2.63e-15 | 6.31e-14 |
Trisomy | APP, BACH1, C2CD2, DYRK1A, ETS2, PCP4, PSMG1, TTC3, | 2.17e-11 | 4.17e-10 |
Down-regulated genes in trisomy 21 | |||
Cystitis | GJC1, TICAM2 | 6.77e-05 | 3.40e-04 |
Metaplasia | ANPEP, EFNB2, HGF | 3.00e-04 | 5.01e-03 |
Pathologic neovascularization | ANPEP, EFNB2, HGF | 2.00e-04 | 5.00e-03 |
Airway obstruction | GPC4, WLS | 6.00e-04 | 7.50e-03 |
Diabetes mellitus | ADAMTS9, C4orf32, CDKAL1 | 1.00e-03 | 1.00e-02 |
Chromosomes other than HSA21 | |||
Pathologic Neovascularization | ANPEP, FLT1, EFNB2, HGF, MET | 2.88e-06 | 3.00e-04 |
Gestational diabetes | ADAMTS9, CDKAL1, FLT1, LEP, | 3.76e-06 | 3.00e-04 |
Metaplasia | ANPEP, EFNB2, FLT1, HGF, MET | 5.67e-06 | 3.00e-04 |
Cystitis | GJC1, TICAM2 | 3.00e-04 | 5.40e-03 |
Vascular Diseases | FLT1, HGF, LEP, NCEH1, OLR1 | 3.00e-04 | 5.40e-03 |