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Table 6 Disease association of candidate genes

From: Genome-wide gene expression analysis in the placenta from fetus with trisomy 21

Disease Gene symbol rawP adjP
Whole genome
 Up-regulated genes in trisomy 21
  Trisomy21 APP, ATP5O, BACE2, BACH1, BRWD1, BTG3, C2CD2, C21orf33, CRYZL1, DONSON, DYRK1A, ETS2, GART, GCFC1, NDUFV3, MCM3AP, MIS18A, PCP4, PSMG1, SETD4, SON, TTC3, UBE2G2,USP25 6.04e-34 5.80e-32
  Chromosome disorders APP, BACE2, BACH1, BRWD1, C2CD2, C21orf33, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, SYNJ1, TRAPPC10, TTC3, UBE2G2, USP25 3.83e-20 1.84e-18
  Mental retardation APP, BACE2, BACH1, BRWD1, C2CD2, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, STXBP1, TTC3, UBE2G2, USP25 4.89e-17 1.56e-15
  Neurobehavioral manifestations APP, BACE2, BACH1, BRWD1, C2CD2, CRYZL1, DYRK1A, ETS2, GART, PCP4, PSMG1, SETD4, SON, TTC3,UBE2G2, USP25 2.63e-15 6.31e-14
  Trisomy APP, BACH1, C2CD2, DYRK1A, ETS2, PCP4, PSMG1, TTC3, 2.17e-11 4.17e-10
 Down-regulated genes in trisomy 21
  Cystitis GJC1, TICAM2 6.77e-05 3.40e-04
  Metaplasia ANPEP, EFNB2, HGF 3.00e-04 5.01e-03
  Pathologic neovascularization ANPEP, EFNB2, HGF 2.00e-04 5.00e-03
  Airway obstruction GPC4, WLS 6.00e-04 7.50e-03
  Diabetes mellitus ADAMTS9, C4orf32, CDKAL1 1.00e-03 1.00e-02
Chromosomes other than HSA21
 Pathologic Neovascularization ANPEP, FLT1, EFNB2, HGF, MET 2.88e-06 3.00e-04
 Gestational diabetes ADAMTS9, CDKAL1, FLT1, LEP, 3.76e-06 3.00e-04
 Metaplasia ANPEP, EFNB2, FLT1, HGF, MET 5.67e-06 3.00e-04
 Cystitis GJC1, TICAM2 3.00e-04 5.40e-03
 Vascular Diseases FLT1, HGF, LEP, NCEH1, OLR1 3.00e-04 5.40e-03
  1. HSA21 human chromosome 21, rawP: p value from hypergeometric test, adjP: p value adjusted by the multiple test adjustment