Subset of neurotrophin signaling pathway genes as the target of the survival significant miRNAs representing two subsets of the19-miRNA and 21-miRNA prognostic classifiers. a Bipartite graphs link the survival significant miRNAs of the 19-miRNA and 21-miRNA classifiers with their target mRNAs are presented for the 9 representative mRNAs. The experimentally supported and ToTGS prediction score positive mRNAs are included in common 21 mRNA subset shown on Figure 6d. Selected mRNAs are common targets for the miRNAs belonging to the 19-miRNA, 21-miRNA and 31-miRNA classifiers. b, c: According to our prognostic model, miRNA-214-3p able to control an expression of multiple target mRNAs resulted in the reproducible pro-oncogenic function in both the TCGA and Shih’s datasets. Details are presented in Additional file 2: Tables S20-S21.