A molecular view of the normal human thyroid structure and function reconstructed from its reference transcriptome map

Table 3 List of the five (or more) most over- or underexpressed genes (all significantly, with q < 0.05, except genes with ^a note) in the Thyroid (Pool A) vs. Pool of non-thyroid tissues samples (Pool B) transcriptome map

Gene name	Value A	Value B	Ratio A/B	Location	Data points A	Data points B	SD as % of expression A	SD as % of expression B
Overexpressed genes
TG	8,662.34	46.02	188.22	8q24	33	566	33.14	221.41
TPO	2,245.11	14.85	151.17	2p25	35	560	54.57	118.35
Hs.654670^ab	1,727.93	12.30	140.54	8q24	18	413	86.71	108.60
SLC26A7	1,107.90	16.55	66.94	8q23	53	1,198	132.82	226.70
IYD	890.07	13.44	66.25	6q25.1	24	456	65.51	137.47
Hs.656634^ab	1,982.24	39.54	50.14	2q13	18	413	80.05	101.09
TSHR	487.64	9.88	49.36	14q31	92	1,907	91.14	130.07
Overexpressed chr21 genes
TFF3	2,726.93	168.96	16.14	21q22.3	36	758	78.82	210.27
Hs.129583^b	273.20	24.62	11.10	21q22.13	11	296	51.98	69.50
DNMT3L	101.54	13.76	7.38	21q22.3	31	449	357.89	107.64
IFNAR1	272.52	45.93	5.93	21q22.11	65	1,405	491.61	75.21
Hs.709790^ab	1,358.90	231.48	5.87	21q22.11	18	418	56.76	78.65
Under-expressed genes
LCE5A	24.09	1,639.23	0.01	1q21.3	11	30	30.42	39.05
MSMB	9.44	527.57	0.02	10q11.2	53	1,152	124.26	347.24
PRM2 ^a	6.51	309.26	0.02	16p13.2	44	553	49.00	530.15
KRTDAP	11.24	480.77	0.02	19q13.12	16	454	39.24	354.39
ORM2	6.19	255.66	0.02	9q32	21	529	38.82	477.48
Underexpressed chr21 genes
S100B	15.70	259.61	0.06	21q22.3	44	865	111.12	324.61
TFF1	22.66	184.51	0.12	21q22.3	33	652	108.08	280.42
KRTAP10-10	14.16	91.19	0.16	21q22.3	16	30	46.04	92.21
OLIG1	12.59	76.13	0.17	21q22.11	24	481	59.64	350.79
TPTE	11.07	53.19	0.21	21p11	21	559	76.74	465.37

‘Value’: mean gene expression value normalized across all the pool samples; ‘Data points’: number of spots associated to an expression value for the locus; ‘SD’: standard deviation for the expression value expressed as a percentage of the mean. Overexpressed genes are sorted by decreasing gene expression ratio, underexpressed genes are sorted by increasing gene expression ratio. Full results are available as supplementary material (see text). ^aThis gene is one of the five most over−/underexpressed ones, but the value is not statistically significant. This is either because this gene was present with other genes even in the 12,500 bp segment and its expression value does not prevail over the others, or because the segment containing the gene does not fulfil criteria for local over−/underexpression ^bCytoband not available in Gene was derived from the UCSC Genome Browser (http://genome-euro.ucsc.edu/cgi-bin/hgGateway)
When there are more than five genes listed, it is because we believe it is important to highlight them

ISSN: 1471-2164