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Fig. 1 | BMC Genomics

Fig. 1

From: Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets

Fig. 1

Gene tree showing the relationships between previously known plasmid-mediated qnr sequences and the sequences validated in this work. The gene tree was produced with ETE 3 using the “standard_fasttree” workflow [50,51,52]. The non-qnr peptapeptide repeat protein MfpA was used as an outlier to root the tree. The bar plot shows fold change of ciprofloxacin minimum inhibitory concentrations for all the tested sequences from three separate measurements each. MIC values for QnrD1, QnrS1, and QnrC for the first time point were taken from our previous study [23]. Wadden 4 did not display an average increase in MIC. Refer to Table 2 for a detailed listing of all sequences discovered in this work, and to Additional file 5: Table S3 for the raw MIC measurement data

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