Skip to main content
Fig. 7 | BMC Genomics

Fig. 7

From: Ancient human miRNAs are more likely to have broad functions and disease associations than young miRNAs

Fig. 7

Human miRNAs within the same family are more functionally similar than other miRNAs. (a) miRNAs within the same family have more similar tissue expression profiles to one another than singleton miRNAs and miRNAs in different families to one another (P = 9.6e–248 and 1.3e–200, Mann-Whitney U test). (b) The genes targeted by miRNAs within the same family are significantly more similar than among singleton and between family miRNAs (P ≈ 0 for both). (c) The diseases associated with human miRNAs in the same family are significantly more similar than between singleton miRNAs and miRNAs in different families (P ≈ 0 for both). (d-f) These results also hold when the miRNAs are stratified by age (P < 2e-16 for each, stratified Mann-Whitney U test)

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us