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Fig. 1 | BMC Genomics

Fig. 1

From: The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae

Fig. 1

Maf-S-cnc-Keap1 pathway. The binding of the ubiquitin ligase Keap1 to cnc results in proteasomal degradation of cnc in the absence of oxidative stress. Under oxidative stress conditions, proteolysis is blocked and cnc is released by Keap1, which translocates into the nucleus and binds to Maf-S. The cnc-Maf-S complex then binds to antioxidant response elements (ARE) in the genome, initiating transcription. Adapted from [30]

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BMC Genomics

ISSN: 1471-2164

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