Fig. 1
From: 5-hydroxymethylcytosine is highly dynamic across human fetal brain development
5hmC is highly dynamic across human fetal brain development. a The presence or absence of detectable 5hmC at individual sites is highly variable amongst the fetal brain samples profiled in this study. Shown is the proportion of probes with detectable 5hmC as a function of the fetal brain samples profiled. Only a small number of probes are characterized by ubiquitously detectable 5hmC in all samples, highlighting considerable inter-individual heterogeneity at individual probes. b The top-ranked dDHP characterized by increasing 5hmC with days post-conception (DPC) is cg25069807, annotated to TK1 on chromosome 17 (P = 2.52E-09). c The top-ranked dDHP characterized by decreasing 5hmC with brain development is cg22960621, annotated to NLGN1 on chromosome 3 (P = 1.42E-09). Males are depicted in black. The dashed line indicates values above which 5hmC is considered to be reliably detected (ΔβBS-oxBS > 0.036). The full list of 2181 dDHPs (P < 5.00E-05) is presented in Additional file 1: Table S5. d The top-ranked dDHR associated with fetal brain development spans a 685 bp region (Chr22: 46,449,430–46,450,115) encompassing the first exon of C22orf26 and LOC150381. The dDHR is denoted by dashed vertical lines. Chromosomal coordinates correspond to human genome build GRCh37/hg19. See Additional file 1: Table S8 for a full list of dDHRs associated with human brain development