Fig. 2
From: 5-hydroxymethylcytosine is highly dynamic across human fetal brain development
There is a complex interaction between 5hmC and 5mC across human brain development. a DNA hydroxymethylation levels are highest at sites characterized by intermediate levels of DNA methylation. Mean DNA hydroxymethylation versus mean DNA methylation is shown for all autosomal probes included in the final dataset (n = 298,972). b Scatterplot showing the regression coefficients for 5hmC and 5mC for each of the 2181 dDHPs (P < 5.00E-05). Nearly half of the dDHPs (n = 1059, 48.56%) are characterized by a significant interaction (P < 2.29E-05) between 5hmC and 5mC across brain development (significant sites are shown in red). Examples of sites at which fetal brain development is associated with (c) increases in both 5hmC and 5mC, (d) decreases in both 5hmC and 5mC, (e) an increase in 5mC but a decrease in 5hmC, (f) a decrease in 5mC but an increase in 5hmC and (g) a change in 5hmC but no alteration in 5mC. 5mC data shown as diamonds, 5hmC data shown as circles. Male samples are indicated by a filled diamond or circle