Fig. 3
From: 5-hydroxymethylcytosine is highly dynamic across human fetal brain development
Levels of 5hmC in the human fetal brain are significantly lower on the X-chromosome in females than males. a Manhattan plot showing the distribution of sites characterized by different levels of 5hmC between males and females. P-value corresponds to association with sex. Points above the X-axis indicate higher 5hmC in females, with those below the X-axis indicating higher 5hmC in males. The red line represents a Bonferroni-corrected significance threshold (P < 1.62E-07) for the 307,810 autosomal and X chromosome probes analyzed. The blue line corresponds to our “discovery” P-value threshold (P < 5E-05). b The top-ranked sex-associated DHP characterized by greater 5hmC in males is cg07806797, annotated to ZNF185 on the X-chromosome (P = 7.19E-20). c The top-ranked sDHP characterized by greater 5hmC in females is cg2678647, annotated to USP11 on the X-chromosome (P = 3.64E-16). d Mean 5hmC across canonical gene features is shown for males and females (pink and blue, respectively) for autosomes (top panel) and the X-chromosome (bottom panel)