Genome-wide association study reveals putative role of gga-miR-15a in controlling feed conversion ratio in layer chickens

Table 4 Significant KEGG pathways for target genes of gga-mir-15a

KEGG^a pathway	Count	%	Involved genes	P value	Benjamini^b
Insulin signaling pathway	12	2.48	PDPK1, PRKAR2A, CRKL, PHKA1, SOS2, FOXO1, RAF1, MAPK8, IRS1, INSR, PIK3R1, AKT3	1.64E-03	4.90E-02
mTOR signaling pathway	8	1.65	PDPK1, RPS6KA3, ULK1, CAB39, RICTOR, IRS1, PIK3R1, AKT3	1.18E-03	0.05
FoxO signaling pathway	13	2.69	USP7, SGK1, FOXO1, RAF1, IRS1, CCND1, PDPK1, CDKN2B, SOS2, MAPK8, INSR, AKT3, PIK3R1	6.79E-04	0.06
Oocyte meiosis	9	1.86	CCNE1, RPS6KA3, YWHAH, CPEB2, CPEB3, BTRC, PPP2R5C, YWHAQ, ITPR2	0.01	0.20
MAPK signaling pathway	15	3.10	TAOK1, NF1, PPM1A, PTPRR, RAF1, RPS6KA3, CRKL, MAP3K4, MAP3K2, ELK4, SOS2, MAPK8, RAPGEF2, NFATC3, AKT3	0.01	0.21
Wnt signaling pathway	10	2.07	TBL1XR1, CCND1, NKD1, BTRC, LRP6, MAPK8, SIAH1, FZD3, NFATC3, WNT7A	0.02	0.26
Insulin resistance	8	1.65	PDPK1, RPS6KA3, FOXO1, MAPK8, IRS1, INSR, PIK3R1, AKT3	0.04	0.40
Progesterone-mediated oocyte maturation	7	1.45	RPS6KA3, CPEB2, CPEB3, RAF1, MAPK8, PIK3R1, AKT3	0.04	0.42

ISSN: 1471-2164