Fig. 5

Core response of C. albicans during neutrophil infection. Candida genes differentially expressed in hyphae upon neutrophil encounter were considered as core response. Core DEGs were grouped according to their transcript profile at 15 min to 60 min p.i. and plotted for yeast and hyphae. a DEGs induced in hyphae, (b) DEGs repressed in hyphae. (A + B) Genes are called commonly repressed or induced in both morphotypes if in at least one time point in one morphotype a significantly differential expression was detected (≥ 4-fold) and in the other morphotype a regulation of ≥ 2-fold compared to reference was given at any time point (a). Genes are called induced or repressed in hyphae but not in yeast if in at least one time point in hyphae a significantly differential expression (≥ 4-fold) was detected and in yeast no regulation ≥ 2-fold was given at any time point (b). Genes are called induced or repressed in hyphae and repressed or induced in yeast if in at least one time point in hyphae a significantly differential expression (≥ 4-fold) was detected and in yeast significantly differential expression (≥ 4-fold) was given at any time point (c). c GO enrichment analysis of commonly (a) and not commonly induced or repressed genes (b and c). Corresponding sets of up- and down-regulated genes were mapped with the “GO term finder” at CGD (http://www.candidagenome.org/cgi-bin/GO/goTermFinder) to biological processes. Beside the assessment of the statistical significance of the gene set with a calculated p-value, the X-fold enrichment is calculated as ratio of percentages of the cluster frequency of tested gene set and the cluster frequency of genomic background. Red indicates up-regulation, blue indicates down-regulation. Samples from two independent experiments were analyzed, n = 2