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Table 2 Cytokine secretion of neutrophils infected with C. albicans yeasts and hyphae

From: Dual transcriptome of the immediate neutrophil and Candida albicans interplay

Cytokine Secretion Gene Expression (RPKM) h60’/y60’ FC [log2] DEG
Control 60 min y 60 min h 60 min y 60 min h
MIP-1β UP-h CCL4 54.4 171.8 194.5 1.1 2.20 2.35 yes
IL-1β UP-h IL1B 242.3 717.1 960.8 1.3 2.11 2.50 yes
IL-8 UP-h IL8 9325.5 20,837.7 28,971.6 1.4 1.68 2.13 yes
M-CSF UP-h CSF1 10.6 11.8 13.6 1.2 0.68 0.86 no
TNFα UP TNF 30.6 39.6 30.6 0.8 0.90 0.50 no
Gro-α n.s. CXCL1 336.2 643.0 674.5 1.0 1.47 1.52 yes
IL-1α n.s. IL1A 2.6 33.3 37.7 1.1 4.24 4.39 yes
IL-1 ra n.s. IL1RN 225.0 486.0 524.3 1.1 1.65 1.74 yes
IL-18 n.s. IL18 0.8 0.4 0.4 1.0 −0.34 −0.36 no
MIF n.s. MIF 0.8 0.4 0.3 0.7 −0.41 −0.91 no
  1. Neutrophils were infected with dead C. albicans yeast or hypha cells and secreted cytokines were detected by Bio-Plex® at 18 h p.i.. Cytokines were either induced similarly with both (UP), secreted more in the presence of hyphae (UP-h), or not secreted (n.s.). Cytokine gene transcript levels (by RPKM) were analyzed after 60 min of stimulation, transcript levels in the infection with yeast and hyphae were related (h60’/y60’). Cytokine gene fold changes of expression (FC) are displayed after 60 min of cocultivation of neutrophils with C. albicans yeasts or hyphae. Statistically significant DEGs are pointed out