Fig. 10

The cytokine-mediated pathways by pIC in Atlantic salmon MLCs. This figure was adapted from known mammalian pathways [79, 97, 107,108,109]. The up- and down-regulated transcripts by pIC in the present study are drawn in red and green, respectively. The microarray results of stat1 and irf7 were only qPCR-validated for the FO7 group. IFNB/G (interferon beta/gamma), IFNAR (IFN alpha receptor), IL (interleukin), IFNGR (IFN-gamma receptor), TYK2 (tyrosine kinase 2), JAK (Janus kinase), SOCS (suppressor of cytokine signaling), STAT (signal transducer and activator of transcription), IRF (IFN regulatory factor), ISGF3 (IFN-stimulated gene factor 3), ISRE (IFN-sensitive response element), GAF (IFNG-activated factor), GAS (IFNG-activated sequence), ISG15 (IFN-stimulated gene 15), LGP2 (RNA helicase LGP2), IP44 (IFN-induced protein 44-like), HERC (E3 ubiquitin-protein ligase herc), IFIT5 (interferon-induced protein with tetratricopeptide repeats 5). Orange circles show phosphorylation