Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells

Table 3 An immune-related subset of enriched GO terms of pIC-responsive transcripts (overlap between SAM and RP analyses) within each dietary group

GO ID	GO Term^a	Category^b	Number of probes with GO^c		Over/Under
GO ID	GO Term^a	Category^b	Test FO7	Test FO5
GO:0004950	chemokine receptor activity	F	8	8	OVER
GO:0004896	cytokine receptor activity	F	11	14	OVER
GO:0071345	cellular response to cytokine stimulus	P	37	43	OVER
GO:0070098	chemokine-mediated signaling pathway	P	9	9	OVER
GO:0034097	response to cytokine	P	40	50	OVER
GO:0045647	negative regulation of erythrocyte differentiation	P	5	5	OVER
GO:0030219	megakaryocyte differentiation	P	9	9	OVER
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	P	8	8	OVER
GO:0002756	MyD88-independent toll-like receptor signaling pathway	P	8	8	OVER
GO:0006954	inflammatory response	P	25	29	OVER
GO:0034138	toll-like receptor 3 signaling pathway	P	8	8	OVER
GO:0002250	adaptive immune response	P	15	16	OVER
GO:0019221	cytokine-mediated signaling pathway	P	24	27	OVER
GO:0032480	negative regulation of type I interferon production	P	6	6	OVER

^aThis subset of enriched GO terms associated with immune responses was selected using Ancestor Chart feature of the QuickGO website (http://www.ebi.ac.uk/QuickGO). The full list of enriched GO terms is presented in Additional file 7: Table S4
^bF: Molecular Function and P: Biological Process
^cNumbers of probes annotated with each GO term in pIC-responsive gene list overlapping between SAM and RP of each dietary group. Bold numbers indicate a significant over-representation (Fisher’s exact test, FDR < 0.05) in the pIC-responsive gene list of the given dietary treatment, compared to the whole 44K salmon microarray. Total number of probes annotated with at least 1 GO term was 666 and 865 for FO7 and FO5 groups, respectively

ISSN: 1471-2164