Fig. 5

Evolutionary dynamics of tsDMRs and transcription factor binding sites. WashU EpiGenome Browser [80] views of tsDMRs in rat and the orthologous regions in mouse and human. The following tracks are displayed: rat: rat DNA methylation (methylCRF) for blood, brain, and sperm, phastCons conserved elements, TFBSs, and refSeq gene annotation; mouse: mouse DNA methylation (methylCRF/WGBS) for blood, brain, and sperm, 30-way vertebrate phyloP score, TFBSs, and refSeq gene annotation; and human: human DNA methylation (methylCRF/WGBS) for blood, brain, and sperm, 46-way vertebrate phyloP score, TFBSs, and refSeq gene annotation. Rat tsDMRs and their orthologous regions in mouse and human are highlighted in pink rectangles. The predicted TF motifs are represented by the vertical red bars. a Genome browser view of a rat brain DMR and its mouse and human orthologous regions located in the intronic region of the Sez6 gene. b Genome browser view of a rat blood DMR and its mouse and human orthologous regions located in an intronic region of the Erg gene. c Genome browser view of a rat blood DMR and its mouse and human orthologous regions located in an intronic region of the Skap1 gene. d Genome browser view of a rat blood DMR and its orthologous regions in mouse and human located in the downstream region of the Cd6 gene. e Genome browser view of a rat blood DMR and its mouse and human orthologous regions located in an intronic region of Irf2 gene