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Fig. 2 | BMC Genomics

Fig. 2

From: Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Fig. 2

Top: PCA based on 1308 CpG sites significant (FDR < 0.05) in CLL cases and with minimal variation between WBC sub-populations. Bottom: similar analysis with 1308 CpG sites randomly selected from among those with FDR > 0.8 in CLL cases and with minimal variation between WBC sub-populations. The signal intensities employed were denoised for various parameters, including B-cell content (see Methods). The numbers in the Figures on the right indicate the fractional B-cell content of the samples. The Figures on the left show all subjects while those on the right show only the CLL case subjects

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BMC Genomics

ISSN: 1471-2164

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