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Fig. 4 | BMC Genomics

Fig. 4

From: Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Fig. 4

Normalized least squares means (LSM) of DM and DE signal values in the controls and the two TtD groups. Top left: 238 DM signals Bonferroni-significant in the short TtD subgroup; bottom left: 291 DE signals FDR-significant in the short TtD subgroup. Top right: top 20 DM signals observed in all cases; bottom right: Bonferroni -significant DE signals observed in all cases. In the Figures on the right are named the genes associated with the 3 DM or DE signals with the largest changes in each direction (only 2 DM genes show increased methylation with decreasing TtD)

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