Skip to main content

Table 1 The statistical powers and the type-I error rates of RareProb-C and other approaches on the simulation datasets

From: An improved burden-test pipeline for identifying associations from rare germline and somatic variants

PAR

0.02

0.03

0.04

0.05

Approach

Power

Type-I

Power

Type-I

Power

Type-I

Power

Type-I

RareProb-C

100%

34.22%

100%

25.06%

100%

22.33%

100%

24.33%

RareCover

71.67%

5.89%

62.67%

3.97%

54.55%

2.86%

47.73%

1.92%

LRT

99%

0%

100%

0%

100%

0%

100%

0%

LBL

100%

37.47%

100%

37.57%

100%

35.74%

100%

31.19%

BUR(0.95)

100%

55.03%

100%

60.16%

100%

64.85%

100%

59.06%

LiMB

100%

44.99%

100%

48.62%

100%

55.04%

100%

42.82%

CCRS

100%

27.82%

100%

43.49%

100%

56.86%

100%

67.73%

  1. The population attributed risk (PAR) vaires from 0.02 to 0.05. The significance threshold is set to P<0.05