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Table 1 The statistical powers and the type-I error rates of RareProb-C and other approaches on the simulation datasets

From: An improved burden-test pipeline for identifying associations from rare germline and somatic variants

PAR 0.02 0.03 0.04 0.05
Approach Power Type-I Power Type-I Power Type-I Power Type-I
RareProb-C 100% 34.22% 100% 25.06% 100% 22.33% 100% 24.33%
RareCover 71.67% 5.89% 62.67% 3.97% 54.55% 2.86% 47.73% 1.92%
LRT 99% 0% 100% 0% 100% 0% 100% 0%
LBL 100% 37.47% 100% 37.57% 100% 35.74% 100% 31.19%
BUR(0.95) 100% 55.03% 100% 60.16% 100% 64.85% 100% 59.06%
LiMB 100% 44.99% 100% 48.62% 100% 55.04% 100% 42.82%
CCRS 100% 27.82% 100% 43.49% 100% 56.86% 100% 67.73%
  1. The population attributed risk (PAR) vaires from 0.02 to 0.05. The significance threshold is set to P<0.05