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Table 2 Comparison results among RareProb-C and the other 5 state-of-the-art approaches on the type-II error rates

From: An improved burden-test pipeline for identifying associations from rare germline and somatic variants

PAR Causal Type-II error
Approach RareProb-C LRT LBL BUR 0.95 LiMB CCRS
0.02   12.89% 100% 32.99% 23.93% 42.78% 53.17%
0.03 50 15.21% 100% 30.09% 14.96% 57.37% 54.00%
0.04   17.28% 100% 19.78% 11.16% 47.99% 52.02%
0.05   20.90% 100% 25.51% 12.03% 52.76% 52.42%
0.02   12.20% 100% 26.06% 20.15% 56.10% 54.45%
0.03 60 17.05% 100% 26.18% 16.16% 60.48% 53.03%
0.04   20.75% 100% 39.02% 14.87% 65.71% 54.08%
0.05   23.29% 100% 31.14% 19.44% 58.82% 55.45%
0.02   12.29% 100% 31.88% 20.33% 67.80% 52.53%
0.03 70 19.10% 100% 33.11% 20.66% 67.94% 53.88%
0.04   22.39% 100% 33.32% 23.55% 71.77% 55.62%
0.05   22.51% 100% 32.09% 31.37% 75.55% 58.84%
0.02   11.39% 100% 32.66% 9.29% 80.07% 50.16%
0.03 80 17.85% 100% 48.38% 8.38% 76.71% 53.03%
0.04   22.98% 100% 38.21% 31.35% 84.29% 62.57%
0.05   15.57% 100% 42.83% 39.47% 78.66% 67.21%
0.02   11.79% 100% 36.91% 35.63% 91.26% 51.73%
0.03 90 20.42% 100% 40.49% 40.33% 89.29% 61.25%
0.04   21.28% 100% 39.91% 47.99% 91.26% 70.83%
0.05   14.72% 100% 48.87% 55.54% 88.79% 74.26%
  1. The population attributed risk (PAR) still vaires from 0.02 to 0.05 and the number of preset causal variants enumerates from 50 to 90. The significance threshold is set to P<0.05