Fig. 3
From: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer
Network building from deregulated genes in different types of PCR arrays. Interactions between sets of deregulated genes identified by transcriptome comparison of CRC and NT were retrieved from the STRING database (version 10.5) for 5 different PCR arrays: a) Apoptosis, b) Cancer pathway, c) Lipoprotein signaling and cholesterol metabolism, d) Drug metabolism and e) Wnt pathway. The interactions include direct (physical) and indirect (functional) associations. All interaction sources questioned by STRING were used and the minimum required interaction score was 0.4 (medium confidence). The blue color of edges indicated a physical interaction between 2 nodes. The thickness of edges was correlated with score confidence (large for high score). Color intensity of nodes was related to transcriptome deregulation (red for up-regulation and green for down-regulation in CRC as compared to NT). Genes showing a deregulation in more than 75% of CRC were characterized by a bold line of shape node. Star symbols indicated the node showing the highest number of interactions in the network