Genomic regions associated with host response to porcine reproductive and respiratory syndrome vaccination and co-infection in nursery pigs

Table 3 Significantly enriched GO terms for genes near SNPs associated with traits following PRRS vaccination

Trait	SNP List^a	GO term	Fold change	P-value^b
Vaccination VL	2	Sensory perception of chemical stimulus	0.53	4.9E-2
	2.5	Behavior	7.38	4.0E-3
		Response to biotic stimulus	5.98	2.2E-3
		Cell proliferation	3.55	2.4E-2
	3	Behavior	23.09	7.1E-7
		Response to biotic stimulus	18.72	5.4E-8
		Cell proliferation	11.12	5.7E-8
		Locomotion	9.30	1.6E-4
		Cytokine-mediated signaling pathway	7.07	4.4E-4
		Cell surface receptor signaling pathway	2.29	3.5E-2
		Signal transduction	1.96	2.2E-2
		Response to external stimulus	5.82	2.4E-3
		Cellular component movement	4.87	7.4E-4
		Response to stress	3.40	4.8E-3
ADG Non-Vx^c	2	Sensory perception of smell	0.53	1.7E-2
	2.5	–	–	–
	3	–	–	–
ADG Vx	2	G-protein coupled receptor signaling pathway	0.61	2.4E-2
		Cell surface receptor signaling pathway	0.68	7.4E-3
		Sensory perception of smell	< 0.20	1.2E-17
		Sensory perception of chemical stimulus	0.40	2.4E-8
		Sensory perception	0.55	2.6E-5
		Neurological system process	0.69	3.0E-3
		System process	0.73	2.1E-2
	2.5	Sensory perception of smell	< 0.20	7.5E-9
	2.5	Sensory perception of chemical stimulus	0.45	2.4E-2
	3	Sensory perception of smell	< 0.20	4.4E-3

^aSNP List: Lists of SNPs from the GWAS with a –log₁₀ p-value above 2, 2.5 or 3
^b P-value: Bonferroni corrected p-value
^cNon-Vx, Non-Vaccinated: Pigs were either vaccinated (Vx) or not (Non-Vx) for PRRS

ISSN: 1471-2164