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Table 2 Odds ratio statistics for RU player status of COL5A1 gene variants (rs12722 and rs3196378)

From: COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby

Positional comparison Model bOdds Ratio 95% Confidence Interval
rs12722
 All athletes v Controls CC/TT CC/Tcarriers Callele/Tallele 1.70 1.45 1.28 1.19–2.42 1.07–1.97 1.08–1.52
 RU athletes v Controls CC/TT CC/Tcarriers Callele/Tallele 1.76 1.53 1.30 1.22–2.54 1.11–2.09 1.09–1.55
 Forwards v Controls CC/TT CC/Tcarriers Callele/Tallele 1.66 1.53 1.26 1.08–2.54 1.06–2.22 1.02–1.55
 Backs v Controls CC/TT CC/Tcarriers Callele/Tallele 1.92 1.51 1.36 1.19–3.12 1.01–2.27 1.08–1.72
 Back 3 and centres v Controls CC/TT CC/Tcarriers Callele/Tallele 2.30 1.76 1.48 1.29–4.08 1.09–2.78 1.12–1.96
rs3196378
 All athletes v Controls CC/AA CC/Acarriers Callele/Aallele 1.83 1.66 1.32 1.29–2.59 1.22–2.25 1.12–1.56
 RU athletes v Controls CC/AA CC/Acarriers Callele/Aallele 1.88 1.73 1.34 1.31–2.70 1.27–2.37 1.12–1.59
 Forwards v Controls CC/AA CC/Acarriers Callele/Aallele 1.90 1.88 1.34 1.25–2.89 1.31–2.69 1.09–1.66
 Backs v Controls CC/AA CC/Acarriers Callele/Aallele 1.85 1.54 1.33 1.14–2.99 1.02–2.31 1.06–1.68
 Back 3 and centres v Controls CC/AA CC/Acarriers Callele/Aallele 2.25 1.78 1.46 1.27–4.00 1.11–2.84 1.11–1.93
Haplotypes and SNP epistasis
 All athletes v Controls C–C/T–A aCC–CC 1.31 1.97 1.10–1.56 1.44–2.69
 RU athletes v Controls C–C/T–A aCC–CC 1.32 2.11 1.11–1.59 1.53–2.91
 Forwards v Controls C–C/T–A aCC–CC 1.31 2.19 1.05–1.62 1.51–3.16
 Backs v Controls C–C/T–A aCC–CC 1.36 1.86 1.07–1.72 1.29–2.67
 Back 3 and centres v Controls C–C/T–A aCC–CC 1.49 2.35 1.12–1.99 1.47–3.77
  1. aMDR best model versus all other genotype combinations for rs12722 and rs3196378
  2. bAll odds ratios were statistically significant (P < 0.05)