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Table 2 Odds ratio statistics for RU player status of COL5A1 gene variants (rs12722 and rs3196378)

From: COL5A1 gene variants previously associated with reduced soft tissue injury risk are associated with elite athlete status in rugby

Positional comparison Model bOdds Ratio 95% Confidence Interval
rs12722
 All athletes v Controls CC/TT
CC/Tcarriers
Callele/Tallele
1.70
1.45
1.28
1.19–2.42
1.07–1.97
1.08–1.52
 RU athletes v Controls CC/TT
CC/Tcarriers
Callele/Tallele
1.76
1.53
1.30
1.22–2.54
1.11–2.09
1.09–1.55
 Forwards v Controls CC/TT
CC/Tcarriers
Callele/Tallele
1.66
1.53
1.26
1.08–2.54
1.06–2.22
1.02–1.55
 Backs v Controls CC/TT
CC/Tcarriers
Callele/Tallele
1.92
1.51
1.36
1.19–3.12
1.01–2.27
1.08–1.72
 Back 3 and centres v Controls CC/TT
CC/Tcarriers
Callele/Tallele
2.30
1.76
1.48
1.29–4.08
1.09–2.78
1.12–1.96
rs3196378
 All athletes v Controls CC/AA
CC/Acarriers
Callele/Aallele
1.83
1.66
1.32
1.29–2.59
1.22–2.25
1.12–1.56
 RU athletes v Controls CC/AA
CC/Acarriers
Callele/Aallele
1.88
1.73
1.34
1.31–2.70
1.27–2.37
1.12–1.59
 Forwards v Controls CC/AA
CC/Acarriers
Callele/Aallele
1.90
1.88
1.34
1.25–2.89
1.31–2.69
1.09–1.66
 Backs v Controls CC/AA
CC/Acarriers
Callele/Aallele
1.85
1.54
1.33
1.14–2.99
1.02–2.31
1.06–1.68
 Back 3 and centres v Controls CC/AA
CC/Acarriers
Callele/Aallele
2.25
1.78
1.46
1.27–4.00
1.11–2.84
1.11–1.93
Haplotypes and SNP epistasis
 All athletes v Controls C–C/T–A
aCC–CC
1.31
1.97
1.10–1.56
1.44–2.69
 RU athletes v Controls C–C/T–A
aCC–CC
1.32
2.11
1.11–1.59
1.53–2.91
 Forwards v Controls C–C/T–A
aCC–CC
1.31
2.19
1.05–1.62
1.51–3.16
 Backs v Controls C–C/T–A
aCC–CC
1.36
1.86
1.07–1.72
1.29–2.67
 Back 3 and centres v Controls C–C/T–A
aCC–CC
1.49
2.35
1.12–1.99
1.47–3.77
  1. aMDR best model versus all other genotype combinations for rs12722 and rs3196378
  2. bAll odds ratios were statistically significant (P < 0.05)