Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

Wang, Guan; Durussel, Jérôme; Shurlock, Jonathan; Mooses, Martin; Fuku, Noriyuki; Bruinvels, Georgie; Pedlar, Charles; Burden, Richard; Murray, Andrew; Yee, Brendan; Keenan, Anne; McClure, John D.; Sottas, Pierre-Edouard; Pitsiladis, Yannis P.

doi:10.1186/s12864-017-4191-7

Table 1 11 genes differentially expressed at During 2 to 5 and throughout the post rHuEpo administration in the MDS

From: Validation of whole-blood transcriptome signature during microdose recombinant human erythropoietin (rHuEpo) administration

Gene	During 2	During 3	During 4	During 5	Post 1	Post 2	Post 3	During 2	During 3	During 4	During 5	Post 1	Post 2	Post 3
Log2 FC								FC
ALAS2	0.86	0.95	0.80	0.70	−0.82	−1.32	−1.18	1.81	1.93	1.75	1.63	−1.77	−2.50	−2.26
BCL2L1	0.71	0.81	0.79	0.69	−0.67	−0.88	−0.89	1.63	1.75	1.73	1.61	−1.59	−1.84	−1.85
DCAF12	0.60	0.78	0.73	0.66	−0.59	−0.90	−0.89	1.52	1.72	1.66	1.58	−1.50	−1.87	−1.86
EPB42	0.86	0.98	0.88	0.76	−0.89	−1.25	−1.08	1.82	1.97	1.84	1.69	−1.85	−2.37	−2.11
GMPR	0.81	0.94	0.79	0.68	−0.72	−0.94	−0.84	1.75	1.92	1.73	1.60	−1.65	−1.92	−1.79
OSBP2	0.96	1.08	1.05	1.00	−0.89	−1.16	−1.03	1.95	2.12	2.07	2.00	−1.85	−2.23	−2.04
SELENBP1	0.98	1.09	0.97	0.83	−0.90	−1.19	−1.05	1.97	2.13	1.96	1.77	−1.87	−2.29	−2.07
SLC4A1	0.89	1.08	0.96	0.82	−0.87	−1.18	−1.10	1.86	2.12	1.94	1.77	−1.83	−2.26	−2.14
TMOD1	0.65	0.89	0.76	0.61	−0.71	−1.06	−1.00	1.57	1.85	1.70	1.53	−1.64	−2.08	−2.01
TNS1	0.84	1.10	0.98	0.87	−0.94	−1.22	−1.10	1.79	2.14	1.97	1.83	−1.91	−2.34	−2.14
TRIM58	0.73	0.82	0.72	0.67	−0.74	−0.94	−0.97	1.66	1.76	1.65	1.59	−1.67	−1.92	−1.96
Uncorrected P val.								FDR
ALAS2	0.00181	0.00055	0.00337	0.01011	0.00274	0.000003	0.00002	0.00778	0.00173	0.00767	0.02030	0.01443	0.00006	0.00008
BCL2L1	0.00180	0.00038	0.00048	0.00230	0.00317	0.00013	0.00009	0.00778	0.00171	0.00367	0.01678	0.01443	0.00031	0.00025
DCAF12	0.00912	0.00072	0.00157	0.00434	0.01090	0.00014	0.00012	0.01558	0.00193	0.00430	0.01678	0.02482	0.00031	0.00031
EPB42	0.00488	0.00139	0.00416	0.01333	0.00378	0.00007	0.00045	0.01052	0.00300	0.00877	0.02277	0.01551	0.00022	0.00092
GMPR	0.00165	0.00026	0.00200	0.00793	0.00479	0.00034	0.00110	0.00778	0.00152	0.00492	0.01835	0.01679	0.00064	0.00196
OSBP2	0.00024	0.00004	0.00006	0.00014	0.00071	0.00002	0.00009	0.00778	0.00079	0.00252	0.00591	0.01443	0.00008	0.00025
SELENBP1	0.00118	0.00030	0.00129	0.00603	0.00283	0.00011	0.00053	0.00778	0.00152	0.00407	0.01835	0.01443	0.00030	0.00103
SLC4A1	0.00848	0.00148	0.00478	0.01499	0.01016	0.00069	0.00126	0.01511	0.00303	0.00933	0.02458	0.02451	0.00124	0.00215
TMOD1	0.00520	0.00015	0.00105	0.00849	0.00218	0.000010	0.00002	0.01052	0.00152	0.00388	0.01835	0.01443	0.00008	0.00008
TNS1	0.00531	0.00026	0.00114	0.00376	0.00181	0.00007	0.00027	0.01052	0.00152	0.00388	0.01678	0.01443	0.00022	0.00058
TRIM58	0.00190	0.00051	0.00204	0.00450	0.00172	0.00009	0.00004	0.00778	0.00173	0.00492	0.01678	0.01443	0.00026	0.00014

Log2 FC log2 transformed fold-change, FC fold-change, FDR false discovery rate adjusted significance

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Genomics

Contact us