Genes to predict VO2max trainability: a systematic review

Williams, Camilla J.; Williams, Mark G.; Eynon, Nir; Ashton, Kevin J.; Little, Jonathan P.; Wisloff, Ulrik; Coombes, Jeff S.

doi:10.1186/s12864-017-4192-6

BMC Genomics

Table 4 Predictor genes that may influence VO_2max training response

From: Genes to predict VO_2max trainability: a systematic review

Number	Chromosome	Gene	Variant	Race	Genotype/expression and VO_2max training response (+/−/0)**	Author, Date (x = candidate gene study)
1	1	*AMPD1*	rs17602729	Caucasian	TT and CT (−)	Thomaes, 2011 (x); Rico-Sanz, 2003 (x)
2	1	*CAMTA1*	rs884736	Caucasian African-American	AA (−)	Bouchard, 2011; Ghosh, 2013
3	1	ID3	rs11574	Caucasian	TBC	Timmons, 2010
4	1	*RGS18*	rs10921078	Caucasian African-American	GG (−)	Bouchard, 2011
5	1	*RYR2*	rs7531957	Caucasian	TBC	Bouchard, 2011; Ghosh, 2013
6	1	SLC45A1	TBC	Caucasian	TBC	Ghosh, 2013
7	2	ACVR1C	TBC	Caucasian	TBC	Ghosh, 2013
8	2	KCNF1	rs2003298	Caucasian	TBC	Bouchard, 2011
9	2	FLJ44450	rs4952535	Caucasian	G (+)	Bouchard, 2011
10	2	TTN	rs10497520	Caucasian	TBC	Timmons, 2010
11	2	NRP2	rs3770991	Caucasian	TBC	Timmons, 2010
12	3	KCNH8	rs4973706	Caucasian	A (+)	Bouchard, 2011
13	3	*ZIC4*	rs11715829	Caucasian	AA (−)	Bouchard, 2011
14	3	NLGN1	rs2030398	Caucasian	A (+)	Bouchard, 2011
15	3	ADCY5	TBC	Caucasian	TBC	Ghosh, 2013
16	4	CSN1S2B	rs2272040	Caucasian	TBC	Bouchard, 2011
17	4	LOC100289626	rs2053896	Caucasian	A (+)	Bouchard, 2011
18	4	*ACSL1*	rs6552828	Caucasian	AA (−)	Bouchard, 2011; Ghosh, 2013
19	4	SLED1	rs6552828	Caucasian	TBC	Ghosh, 2013
20	4	PRR27; C4orf40	rs3775758	Caucasian	TBC	Ghosh, 2013
21	4	TEC	rs13117386	Caucasian	TBC	Ghosh, 2013
22	5	NR3C1	rs6190	Caucasian	GG (−)	Thomaes, 2011
23	5	NLN	TBC	Caucasian	TBC	Ghosh, 2013
24	5	FABP6	rs7734683	Caucasian	TBC	Ghosh, 2013
25	5	TTC1	rs2176830	Caucasian	TBC	Bouchard, 2011
26	6	PPARD	Exon 4 + 15 Exon 7 + 65	African-American	CC (−)	Hautala, 2007 (x)
27	6	HCG22	rs2517512	Caucasian	TBC	Ghosh, 2013
28	6	HCG22	rs2523849	Caucasian	TBC	Bouchard, 2011
29	6	HCG22	rs2523848	Caucasian	TBC	Bouchard, 2011
30	6	HCG22	rs2428514	Caucasian	TBC	Bouchard, 2011
31	6	HCG22	rs2517518	Caucasian	TBC	Bouchard, 2011
32	6	HCG22	rs2523840	Caucasian	TBC	Bouchard, 2011
33	6	HCG22	rs2517506	Caucasian	TBC	Bouchard, 2011
34	6	PRDM1	rs10499043	Caucasian	A (+)	Bouchard, 2011
35	6	ENPP3	rs10452621	Caucasian	A (+)	Bouchard, 2011
36	6	SLC22A3	rs2457571	Caucasian	Downregulated in high responders	Timmons, 2010
37	6	TMEM181	TBC	Caucasian	TBC	Ghosh, 2013
38	6	PARK2	TBC	Caucasian	TBC	Ghosh, 2013
39	6	SNX14	TBC	Caucasian	TBC	Ghosh, 2013
40	6	BTBD9	TBC	Caucasian	TBC	Ghosh, 2013
41	6	KCNQ5	TBC	Caucasian	TBC	Ghosh, 2013
42	7	HDAC9	rs3814991	Caucasian	TBC	Bouchard, 2011
43	7	WBSCR17	rs12538806	Caucasian	TBC	Bouchard, 2011
44	7	WBSCR17	rs13235325	Caucasian	TBC	Bouchard, 2011
45	7	CPVL	rs4257918	Caucasian	TBC	Timmons, 2010
46	7	ITGB8	rs10265149	Caucasian	TBC	Ghosh, 2013
47	7	LHFPL3	TBC	Caucasian	TBC	Ghosh, 2013
48	8	DEPDC6	rs7386139	Caucasian	TBC	Timmons, 2010
49	8	PINX1	TBC	Caucasian	TBC	Ghosh, 2013
50	9	GRIN3A	rs1535628	Caucasian	TBC	Bouchard, 2011
51	9	GRIN3A	rs959066	Caucasian	TBC	Bouchard, 2011
52	9	C9orf27	rs12115454	Caucasian	G (+)	Bouchard, 2011
53	9	TTLL11	rs7022103	Caucasian	TBC	Ghosh, 2013
54	9	KCNT1	TBC	Caucasian	TBC	Ghosh, 2013
55	10	FAM238B; LOC731789	rs11015207	Caucasian	TBC	Ghosh, 2013
56	10	PRKG1	TBC	Caucasian	TBC	Ghosh, 2013
57	10	SVIL	rs6481619	Caucasian	TBC	Timmons, 2010
58	10	BTAF1	rs2792022	Caucasian	TBC	Timmons, 2010
59	10	CASC2	rs1413184	Caucasian	TBC	Ghosh, 2013
60	11	H19	rs22551375	Caucasian	Upregulated in high responders	Timmons, 2010
61	11	LOC100130460	rs2198009	Caucasian	A (+)	Bouchard, 2011
62	11	DBX1	rs10500872	Caucasian	A (+)	Bouchard, 2011
63	11	*CD44*	rs353625	Caucasian	TBC	Bouchard, 2011; Ghosh, 2013
64	11	CXCR5 (36 kb)	rs4938561	Caucasian	TBC	Bouchard, 2011
65	11	CXCR5 (24 kb)/BLR1	rs7933007	Caucasian	TBC	Bouchard, 2011
66	11	CD6	rs175098	Caucasian	TBC	Ghosh, 2013
67	11	SHANK2	rs10751308	Caucasian	TBC	Ghosh, 2013
68	11	GRIK4	TBC	Caucasian	TBC	Ghosh, 2013
69	11	CNTF	rs1800169	Caucasian	AA (+)	Thomaes, 2011 (x)
70	11	CAT	-262C > T	Caucasian	TT (−)	Onkelinx, 2011 (x)
71	11	GSTP1	c.313A > G (rs1695)	Caucasian	GG & AG (+)	Zarebska, 2014 (x)
72	12	FAM19A2	rs2168452	Caucasian	TBC	Ghosh, 2013
73	12	C12orf36	rs12580476	Caucasian	TBC	Bouchard, 2011 Ghosh, 2013
74	13	NALCN	TBC	Caucasian	TBC	Ghosh, 2013
75	13	MIPEP	rs7324557	Caucasian	TBC	Timmons, 2010
76	13	EEF1DP3	rs2773968	Caucasian	TBC	Ghosh, 2013
77	13	CLYBL	NA	Caucasian	TBC	Ghosh, 2013
78	13	Na + −K + −ATPase α2	Alpha2 exon 1 Alpha2 exon 21–22	Caucasian	3.3/3.3 (−) 10.5/10.5 (+)	Rankinen, 2000a (x)
79	14	HIF1A	T + 140C	Caucasian (60+ years)	C/T (−)	Prior, 2003 (x)
80	14	AKT1	G205 T (RS1130214)	Caucasian men	GT & TT (+)	McKenzie, 2011 (x)
81	14	TTC6	rs12896790	Caucasian	C (+)	Bouchard, 2011
82	14	*DAAM1*	rs1956197	Caucasian	AA (−)	Bouchard, 2011
83	15	*NDN*	rs824205	Caucasian	GG (−)	Bouchard, 2011
84	15	DIS3L	Rs1546570	Caucasian	TBC	Timmons, 2010
85	17	*ACE*	Intron 16	Caucasian	DD (+) II (+)	Rankinen, 2000b (x); Defoor, 2006 (x)
86	17	RPTOR	NA	Caucasian	TBC	Ghosh, 2013
87	17	VPS53	NA	Caucasian	TBC	Ghosh, 2013
88	19	ADGRE3P; EMR4	rs7256163	Caucasian	TBC	Bouchard, 2011
89	19	*APOE*	TBC	Chinese & unknown	E2/E3 (+) E2/E3 (+) E3/E4 (+) E3/E4 (+) E3/E3 (−)	Yu, 2014 (x); Thompson, 2004 (x)
90	19	*CKM*	Ncol	Caucasian	Homozygous 1170 bp (−); CKM locus (+/−)	Rivera, 1999(x); Rivera 1997 (x)
91	20	*BIRC7 and YTHDF1*	rs6090314	Caucasian	A (+)	Bouchard, 2011 Ghosh, 2013
92	20	YTHDF1	rs6122403	Caucasian	TBC	Ghosh, 2013
93	20	MACROD2	NA	Caucasian	TBC	Ghosh, 2013
94	21	HLCS	NA	Caucasian	TBC	Ghosh, 2013
95	22	MN1	rs738353	Caucasian	A (+)	Bouchard, 2011
96	Mitochondria	ALAS2	</=166 bp	Chinese	</=166 bp (+)	Xu, 2015 (x)
97	Mitochondria	mtDNA	TBC	Quebec, Tempe	mtDNA subunit 5 N5 (−)	Dionne, 1991 (x)

Where possible, gene variants were annotated using the references sequence (GRCh37/hg19)
Bolded = genes that have been replicated between or within studies
**(+) = high training response, (−) = low training response, (0) = neutral training response, TBC to be confirmed whether variant contributes to a high or low training response

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ISSN: 1471-2164

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