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Table 4 Predictor genes that may influence VO2max training response

From: Genes to predict VO2max trainability: a systematic review

Number Chromosome Gene Variant Race Genotype/expression and VO2max training response (+/−/0)** Author, Date (x = candidate gene study)
1 1 AMPD1 rs17602729 Caucasian TT and CT (−) Thomaes, 2011 (x); Rico-Sanz, 2003 (x)
2 1 CAMTA1 rs884736 Caucasian
African-American
AA (−) Bouchard, 2011; Ghosh, 2013
3 1 ID3 rs11574 Caucasian TBC Timmons, 2010
4 1 RGS18 rs10921078 Caucasian
African-American
GG (−) Bouchard, 2011
5 1 RYR2 rs7531957 Caucasian TBC Bouchard, 2011; Ghosh, 2013
6 1 SLC45A1 TBC Caucasian TBC Ghosh, 2013
7 2 ACVR1C TBC Caucasian TBC Ghosh, 2013
8 2 KCNF1 rs2003298 Caucasian TBC Bouchard, 2011
9 2 FLJ44450 rs4952535 Caucasian G (+) Bouchard, 2011
10 2 TTN rs10497520 Caucasian TBC Timmons, 2010
11 2 NRP2 rs3770991 Caucasian TBC Timmons, 2010
12 3 KCNH8 rs4973706 Caucasian A (+) Bouchard, 2011
13 3 ZIC4 rs11715829 Caucasian AA (−) Bouchard, 2011
14 3 NLGN1 rs2030398 Caucasian A (+) Bouchard, 2011
15 3 ADCY5 TBC Caucasian TBC Ghosh, 2013
16 4 CSN1S2B rs2272040 Caucasian TBC Bouchard, 2011
17 4 LOC100289626 rs2053896 Caucasian A (+) Bouchard, 2011
18 4 ACSL1 rs6552828 Caucasian AA (−) Bouchard, 2011; Ghosh, 2013
19 4 SLED1 rs6552828 Caucasian TBC Ghosh, 2013
20 4 PRR27; C4orf40 rs3775758 Caucasian TBC Ghosh, 2013
21 4 TEC rs13117386 Caucasian TBC Ghosh, 2013
22 5 NR3C1 rs6190 Caucasian GG (−) Thomaes, 2011
23 5 NLN TBC Caucasian TBC Ghosh, 2013
24 5 FABP6 rs7734683 Caucasian TBC Ghosh, 2013
25 5 TTC1 rs2176830 Caucasian TBC Bouchard, 2011
26 6 PPARD Exon 4 + 15
Exon 7 + 65
African-American CC (−) Hautala, 2007 (x)
27 6 HCG22 rs2517512 Caucasian TBC Ghosh, 2013
28 6 HCG22 rs2523849 Caucasian TBC Bouchard, 2011
29 6 HCG22 rs2523848 Caucasian TBC Bouchard, 2011
30 6 HCG22 rs2428514 Caucasian TBC Bouchard, 2011
31 6 HCG22 rs2517518 Caucasian TBC Bouchard, 2011
32 6 HCG22 rs2523840 Caucasian TBC Bouchard, 2011
33 6 HCG22 rs2517506 Caucasian TBC Bouchard, 2011
34 6 PRDM1 rs10499043 Caucasian A (+) Bouchard, 2011
35 6 ENPP3 rs10452621 Caucasian A (+) Bouchard, 2011
36 6 SLC22A3 rs2457571 Caucasian Downregulated in high responders Timmons, 2010
37 6 TMEM181 TBC Caucasian TBC Ghosh, 2013
38 6 PARK2 TBC Caucasian TBC Ghosh, 2013
39 6 SNX14 TBC Caucasian TBC Ghosh, 2013
40 6 BTBD9 TBC Caucasian TBC Ghosh, 2013
41 6 KCNQ5 TBC Caucasian TBC Ghosh, 2013
42 7 HDAC9 rs3814991 Caucasian TBC Bouchard, 2011
43 7 WBSCR17 rs12538806 Caucasian TBC Bouchard, 2011
44 7 WBSCR17 rs13235325 Caucasian TBC Bouchard, 2011
45 7 CPVL rs4257918 Caucasian TBC Timmons, 2010
46 7 ITGB8 rs10265149 Caucasian TBC Ghosh, 2013
47 7 LHFPL3 TBC Caucasian TBC Ghosh, 2013
48 8 DEPDC6 rs7386139 Caucasian TBC Timmons, 2010
49 8 PINX1 TBC Caucasian TBC Ghosh, 2013
50 9 GRIN3A rs1535628 Caucasian TBC Bouchard, 2011
51 9 GRIN3A rs959066 Caucasian TBC Bouchard, 2011
52 9 C9orf27 rs12115454 Caucasian G (+) Bouchard, 2011
53 9 TTLL11 rs7022103 Caucasian TBC Ghosh, 2013
54 9 KCNT1 TBC Caucasian TBC Ghosh, 2013
55 10 FAM238B; LOC731789 rs11015207 Caucasian TBC Ghosh, 2013
56 10 PRKG1 TBC Caucasian TBC Ghosh, 2013
57 10 SVIL rs6481619 Caucasian TBC Timmons, 2010
58 10 BTAF1 rs2792022 Caucasian TBC Timmons, 2010
59 10 CASC2 rs1413184 Caucasian TBC Ghosh, 2013
60 11 H19 rs22551375 Caucasian Upregulated in high responders Timmons, 2010
61 11 LOC100130460 rs2198009 Caucasian A (+) Bouchard, 2011
62 11 DBX1 rs10500872 Caucasian A (+) Bouchard, 2011
63 11 CD44 rs353625 Caucasian TBC Bouchard, 2011; Ghosh, 2013
64 11 CXCR5 (36 kb) rs4938561 Caucasian TBC Bouchard, 2011
65 11 CXCR5 (24 kb)/BLR1 rs7933007 Caucasian TBC Bouchard, 2011
66 11 CD6 rs175098 Caucasian TBC Ghosh, 2013
67 11 SHANK2 rs10751308 Caucasian TBC Ghosh, 2013
68 11 GRIK4 TBC Caucasian TBC Ghosh, 2013
69 11 CNTF rs1800169 Caucasian AA (+) Thomaes, 2011 (x)
70 11 CAT -262C > T Caucasian TT (−) Onkelinx, 2011 (x)
71 11 GSTP1 c.313A > G (rs1695) Caucasian GG & AG (+) Zarebska, 2014 (x)
72 12 FAM19A2 rs2168452 Caucasian TBC Ghosh, 2013
73 12 C12orf36 rs12580476 Caucasian TBC Bouchard, 2011
Ghosh, 2013
74 13 NALCN TBC Caucasian TBC Ghosh, 2013
75 13 MIPEP rs7324557 Caucasian TBC Timmons, 2010
76 13 EEF1DP3 rs2773968 Caucasian TBC Ghosh, 2013
77 13 CLYBL NA Caucasian TBC Ghosh, 2013
78 13 Na + −K + −ATPase α2 Alpha2 exon 1
Alpha2 exon 21–22
Caucasian 3.3/3.3 (−)
10.5/10.5 (+)
Rankinen, 2000a (x)
79 14 HIF1A T + 140C Caucasian (60+ years) C/T (−) Prior, 2003 (x)
80 14 AKT1 G205 T (RS1130214) Caucasian men GT & TT (+) McKenzie, 2011 (x)
81 14 TTC6 rs12896790 Caucasian C (+) Bouchard, 2011
82 14 DAAM1 rs1956197 Caucasian AA (−) Bouchard, 2011
83 15 NDN rs824205 Caucasian GG (−) Bouchard, 2011
84 15 DIS3L Rs1546570 Caucasian TBC Timmons, 2010
85 17 ACE Intron 16 Caucasian DD (+)
II (+)
Rankinen, 2000b (x); Defoor, 2006 (x)
86 17 RPTOR NA Caucasian TBC Ghosh, 2013
87 17 VPS53 NA Caucasian TBC Ghosh, 2013
88 19 ADGRE3P; EMR4 rs7256163 Caucasian TBC Bouchard, 2011
89 19 APOE TBC Chinese & unknown E2/E3 (+)
E2/E3 (+)
E3/E4 (+)
E3/E4 (+)
E3/E3 (−)
Yu, 2014 (x); Thompson, 2004 (x)
90 19 CKM Ncol Caucasian Homozygous 1170 bp (−); CKM locus (+/−) Rivera, 1999(x); Rivera 1997 (x)
91 20 BIRC7 and YTHDF1 rs6090314 Caucasian A (+) Bouchard, 2011
Ghosh, 2013
92 20 YTHDF1 rs6122403 Caucasian TBC Ghosh, 2013
93 20 MACROD2 NA Caucasian TBC Ghosh, 2013
94 21 HLCS NA Caucasian TBC Ghosh, 2013
95 22 MN1 rs738353 Caucasian A (+) Bouchard, 2011
96 Mitochondria ALAS2 </=166 bp Chinese </=166 bp (+) Xu, 2015 (x)
97 Mitochondria mtDNA TBC Quebec, Tempe mtDNA subunit 5 N5 (−) Dionne, 1991 (x)
  1. Where possible, gene variants were annotated using the references sequence (GRCh37/hg19)
  2. Bolded = genes that have been replicated between or within studies
  3. **(+) = high training response, (−) = low training response, (0) = neutral training response, TBC to be confirmed whether variant contributes to a high or low training response