Fig. 1
From: Physical activity in the prevention of human diseases: role of epigenetic modifications
Small-scale intervention protocols from human and animal studies focusing on the exercise-related epigenetic modulations in human diseases and/or in specific disease candidate genes. * Exercise-induced hypermethylation (ADAMT59, CPEB4, GRB14, ITPR2, LY86, LYPLAL1, MAP2K5, MSRA, MTIF3, MRXN3, PRKD1, SOCCAG8, STAB1, TBX15, TMEM160, ZNF608) or hypomethylation (GPRC58, TUB) in obesity candidate genes [85]. **Exercise-induced hypermethylation (ADAMT59, ADCY5, ARAP1, BCL11A, CDKAL1, CDKN2A, DGKB, DUSP8, FTO, HHEX, HMGA2, IGF2BP2, JAZF1, KCNQ1, PRC1, PROX1, PTPRD, TCF7L2, THADA, WFS1, ZBED3) or hypomethylation (KCNQ1, TCF7L2) in T2D candidate genes [85]