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Table 1 Frequency of KEGG Orthologs in the imputed metagenome of the murine nasal microbiome calculated using Tax4Fun

From: IL-17 signalling restructures the nasal microbiome and drives dynamic changes following Streptococcus pneumoniae colonization

KEGG Orthology Classification Abundance of mapped genes, % (IQR) q value
Wild Type IL-17RAKO
Metabolism
 Carbohydrate metabolism 13.16 (0.6) 13.59 (0.16) 0.27
 Energy Metabolism 7.22 (1.14) 6.35 (0.37) 0.24
 Lipid metabolism 3.48 (0.36) 3.45 (0.04) 0.71
 Nucleotide metabolism 6.27 (0.38) 6.54 (0.43) 0.27
 Amino acid metabolism 11.25 (0.39) 10.78 (0.35) 0.27
 Metabolism of other amino acids 2.69 (0.08) 2.73 (0.09) 0.27
 Glycan biosynthesis and metabolism 2.85 (0.13) 3.36 (0.26) 0.0016
 Metabolism of cofactors and vitamins 8.28 (2.01) 7.63 (0.22) 0.45
 Metabolism of terpenoids and polyketides 2.89 (0.15) 2.40 (0.17) 0.0074
 Metabolism of other secondary metabolites 0.767 (0.08) 0.651 (0.09) 0.0016
 Xenobiotics degradation and metabolism 3.41 (0.78) 2.78 (0.43) 0.039
Genetic information processing
 Transcription 0.275 (0.04) 0.273 (0.04) 0.75
 Translation 5.95 (0.76) 6.05 (0.97) 0.69
 Folding, sorting and degradation 2.75 (0.33) 2.87 (0.27) 0.28
 Replication and repair 5.55 (0.65) 5.71 (0.62) 0.56
Environmental information processing
 Membrane transport 11.09 (1.59) 12.51 (0.5) 0.13
 Signal transduction 5.60 (1.17) 5.61 (1.09) 0.77
 Signaling molecules and interaction 0.000276 (0) 0.000106 (0) 0.025
Cellular processes
 Transport and catabolism 0.266 (0.07) 0.259 (0.02) 0.68
 Cell motility 1.27 (0.6) 1.03 (0.62) 0.28
 Cell growth and death 1.52 (0.08) 1.39 (0.04) 0.0016
Human disease
 Infectious Diseases: Bacterial 1.84 (0.14) 2.42 (0.29) 0.0019
  1. Differences were analysed using Mann-Whitney tests corrected for multiple comparisons using the method of Benjamini, Krieger and Yekutieli with a false discovery rate of 1%. Significant differences between Wild type and IL-17RAKO animals are shown in bold ( q value < 0.01)