Skip to main content

Table 6 Enriched genetic pathways in all comparisons from in IPA

From: Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology

Pathway name Genes Total no. of genes in pathway P value
Restricted Anovulatory v Control
 Activation of IRF by Cystosolic Pattern Recognition Receptors DDX58 ↑, IFIH1 ↑, IFIT2 ↑, ZBP1 72 0.00073
 Interferon Signalling IFIT1 ↑, IFIT3 ↑, MX1 36 0.00135
 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza CXCL10 ↑, IL8 ↑, IL1A 44 0.00286
 Synaptic Long Term Potentiation ADCY1 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 114 0.00461
 CREB Signalling in Neurons ADCY1 ↓, GRIK3 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 202 0.00515
 Calcium Signalling CHRNA2 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 ↓, MYH11 207 0.00541
 Glutamate Receptor Signalling GRIK3 ↓, GRIN2A ↓, GRIN2C 69 0.00595
 D-arginine and D-ornithine Metabolism DAO 18 0.00646
 Glycosphingolipid Biosynthesis – Neolactoseries ST3GAL6 ↑, ST8SIA5 64 0.00957
Restricted Ovulatory v Control
 Gα12/13 Signalling CDH1 ↓, F2R 128 0.00767
Restricted Anovulatory v Restricted Ovulatory
 LXR/RXR Activation APOA4 ↓, CCL2 ↑, CD14 ↑, IL1A ↑, IL1B ↑, MSR1 ↑, NR1H2 ↓, PTGS2 ↑, RXRG ↑, SREBF1 ↓, TLR3 ↑, TLR4 93 0.000344
 Germ Cell-Sertoli Cell Junction Signaling A2M ↑, ACTG2 ↑, AXIN1 ↓, BCAR1 ↓, EPN1 ↓, EPN2 ↓, GSN ↓, IQGAP1 ↑, JUP ↓, LAMC3 ↓, MAP3K9 ↓, MAP3K11 ↓, PIK3CD ↓, PVRL2 ↓, RHOT2 ↓, RND3 ↑, TUBA8 ↓, ZYX 167 0.000870
 TREM1 Signaling CASP5 ↑, CCL2 ↑, CD86 ↑, FCGR2B ↑, ICAM1 ↑, IL1B ↑, TLR2 ↑, TLR3 ↑, TLR4 66 0.00125
 Neuropathic Pain Signaling In Dorsal Horn Neurons GRIN2A ↓, GRIN2B ↓, GRIN2C ↓, GRM4 ↓, KCNH2 ↓, KCNN1 ↓, KCNQ2 ↓, KCNQ3 ↓, PIK3CD ↓, PLCH2 ↓, PRKCG ↓, PRKCH ↓, TAC1 108 0.00133
 Hepatic Fibrosis / Hepatic Stellate Cell Activation A2M ↑, AGTR1 ↓, CCL2 ↑, CCR5 ↑, CD14 ↑, CXCL9 ↑, FLT1 ↑, ICAM1 ↑, IGFBP5 ↓, IL1A ↑, IL1B ↑, KDR ↑, MYH11 ↑, MYH14 ↓, STAT1 ↑, TLR4 147 0.00159
 Reelin Signalling in Neurons APBB1 ↓, ARHGEF1 ↓, ARHGEF10 ↓, ARHGEF16 ↓, CDK5R1 ↓, MAP3K9 ↓, MAP3K11 ↓, MAPK8IP1 ↓, MAPK8IP3 ↓, PIK3CD ↓, RELN 82 0.00175
 G-Protein Coupled Receptor Signalling ADCY1 ↓, AGTR1 ↓, APLNR ↑, C3AR1 ↑, CALCRL ↑, CCKAR ↑, CCR5 ↑, CRHR1 ↓, CX3CR1 ↑, CXCR7 ↓, DUSP4 ↓, ELTD1 ↑, F2R ↑, FZD6 ↑, GPR17 ↓, GPR83 ↑, GPR116 ↑, GPR123 ↓, GPR126 ↑, GPR133 ↑, GPR137 ↓, GPR153 ↓, GPR179 ↑, GPR172B ↓, GRM4 ↓, HRH1 ↑, HTR2A ↑, LPHN3 ↑, MC4R ↑, NTSR1 ↓, PDE8B ↑, PIK3CD ↓, PRKCG ↓, PTGFR ↑, PTK2B ↓, RAPGEF3 ↓, RGR ↓, RGS16 ↓, S1PR5 ↓, TSHR 529 0.00314
 Circadian Rhythm signalling ADCYAP1 ↑, CRY2 ↓, GRIN2A ↓, GRIN2B ↓, GRIN2C ↓, PER1 35 0.00374
 Axonal Guidance Signalling ABLIM3 ↑, ADAM11 ↓, ADAM15 ↓, ADAM28 ↑, BCAR1 ↓, CXCR4 ↑, EFNA5 ↑, EPHB6 ↓, FZD6 ↑, GIT1 ↓, GNB1L ↓, GNG4 ↑, GNG7 ↓, LINGO1 ↓, MAG ↓, PIK3CD ↓, PLXNA2 ↓, PLXNB1 ↓, PLXNC1 ↑, PRKCG ↓, PRKCH ↓, SEMA3E ↓, SEMA4C ↓, SEMA4D ↓, SEMA4F ↑, SEMA6B ↓, SEMA7A ↓, SLIT1 ↑, SLIT2 ↑, TUBA8 ↓, UNC5B 432 0.00706
 Glycerolipid Metabolism ALDH1A1 ↓, ALDH4A1 ↓, DAGLA ↓, DGAT2 ↑, DGKQ ↓, DHRS4 ↓, GLYCTK ↓, LIPE ↓, LIPN3 ↓, MGLL ↓, PPAP2C ↓, 148 0.00798
 Pathogenesis of Multiple Schlerosis CCR5 ↑, CXCL9 ↑, CXCL10 9 0.00819