Table 6 Enriched genetic pathways in all comparisons from in IPA

 Activation of IRF by Cystosolic Pattern Recognition Receptors

DDX58 ↑, IFIH1 ↑, IFIT2 ↑, ZBP1 ↑

 Interferon Signalling

IFIT1 ↑, IFIT3 ↑, MX1 ↑

 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

CXCL10 ↑, IL8 ↑, IL1A ↑

 Synaptic Long Term Potentiation

ADCY1 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 ↓

 CREB Signalling in Neurons

ADCY1 ↓, GRIK3 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 ↓

 Calcium Signalling

CHRNA2 ↓, GRIN2A ↓, GRIN2C ↓, ITPR1 ↓, MYH11 ↑

 Glutamate Receptor Signalling

GRIK3 ↓, GRIN2A ↓, GRIN2C ↓

 D-arginine and D-ornithine Metabolism

DAO ↓

 Glycosphingolipid Biosynthesis – Neolactoseries

ST3GAL6 ↑, ST8SIA5 ↓

 Gα12/13 Signalling

CDH1 ↓, F2R ↓

 LXR/RXR Activation

APOA4 ↓, CCL2 ↑, CD14 ↑, IL1A ↑, IL1B ↑, MSR1 ↑, NR1H2 ↓, PTGS2 ↑, RXRG ↑, SREBF1 ↓, TLR3 ↑, TLR4 ↑

 Germ Cell-Sertoli Cell Junction Signaling

A2M ↑, ACTG2 ↑, AXIN1 ↓, BCAR1 ↓, EPN1 ↓, EPN2 ↓, GSN ↓, IQGAP1 ↑, JUP ↓, LAMC3 ↓, MAP3K9 ↓, MAP3K11 ↓, PIK3CD ↓, PVRL2 ↓, RHOT2 ↓, RND3 ↑, TUBA8 ↓, ZYX ↓

 TREM1 Signaling

CASP5 ↑, CCL2 ↑, CD86 ↑, FCGR2B ↑, ICAM1 ↑, IL1B ↑, TLR2 ↑, TLR3 ↑, TLR4 ↑

 Neuropathic Pain Signaling In Dorsal Horn Neurons

GRIN2A ↓, GRIN2B ↓, GRIN2C ↓, GRM4 ↓, KCNH2 ↓, KCNN1 ↓, KCNQ2 ↓, KCNQ3 ↓, PIK3CD ↓, PLCH2 ↓, PRKCG ↓, PRKCH ↓, TAC1 ↑

 Hepatic Fibrosis / Hepatic Stellate Cell Activation

A2M ↑, AGTR1 ↓, CCL2 ↑, CCR5 ↑, CD14 ↑, CXCL9 ↑, FLT1 ↑, ICAM1 ↑, IGFBP5 ↓, IL1A ↑, IL1B ↑, KDR ↑, MYH11 ↑, MYH14 ↓, STAT1 ↑, TLR4 ↑

 Reelin Signalling in Neurons

APBB1 ↓, ARHGEF1 ↓, ARHGEF10 ↓, ARHGEF16 ↓, CDK5R1 ↓, MAP3K9 ↓, MAP3K11 ↓, MAPK8IP1 ↓, MAPK8IP3 ↓, PIK3CD ↓, RELN ↑

 G-Protein Coupled Receptor Signalling

ADCY1 ↓, AGTR1 ↓, APLNR ↑, C3AR1 ↑, CALCRL ↑, CCKAR ↑, CCR5 ↑, CRHR1 ↓, CX3CR1 ↑, CXCR7 ↓, DUSP4 ↓, ELTD1 ↑, F2R ↑, FZD6 ↑, GPR17 ↓, GPR83 ↑, GPR116 ↑, GPR123 ↓, GPR126 ↑, GPR133 ↑, GPR137 ↓, GPR153 ↓, GPR179 ↑, GPR172B ↓, GRM4 ↓, HRH1 ↑, HTR2A ↑, LPHN3 ↑, MC4R ↑, NTSR1 ↓, PDE8B ↑, PIK3CD ↓, PRKCG ↓, PTGFR ↑, PTK2B ↓, RAPGEF3 ↓, RGR ↓, RGS16 ↓, S1PR5 ↓, TSHR ↑

 Circadian Rhythm signalling

ADCYAP1 ↑, CRY2 ↓, GRIN2A ↓, GRIN2B ↓, GRIN2C ↓, PER1 ↓

 Axonal Guidance Signalling

ABLIM3 ↑, ADAM11 ↓, ADAM15 ↓, ADAM28 ↑, BCAR1 ↓, CXCR4 ↑, EFNA5 ↑, EPHB6 ↓, FZD6 ↑, GIT1 ↓, GNB1L ↓, GNG4 ↑, GNG7 ↓, LINGO1 ↓, MAG ↓, PIK3CD ↓, PLXNA2 ↓, PLXNB1 ↓, PLXNC1 ↑, PRKCG ↓, PRKCH ↓, SEMA3E ↓, SEMA4C ↓, SEMA4D ↓, SEMA4F ↑, SEMA6B ↓, SEMA7A ↓, SLIT1 ↑, SLIT2 ↑, TUBA8 ↓, UNC5B ↓

 Glycerolipid Metabolism

ALDH1A1 ↓, ALDH4A1 ↓, DAGLA ↓, DGAT2 ↑, DGKQ ↓, DHRS4 ↓, GLYCTK ↓, LIPE ↓, LIPN3 ↓, MGLL ↓, PPAP2C ↓,

 Pathogenesis of Multiple Schlerosis

CCR5 ↑, CXCL9 ↑, CXCL10 ↑