Fig. 3
From: ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis
Extrinsic apoptosis pathway members identified by ENCoRE following TNFa challenge. a ENCoRE’s CRISPR Report Module indexing method produces a volcano plot that combines fold change with p-values. Higher scoring genes appear farther right and near the top. Known apoptosis genes and new candidate genes chosen for validation are highlighted. b Comparison of top 20 ranked genes identified by ENCoRE, MAGeCK and edgeR following TNFa challenge shows substantial overlap between top hits