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Table 3 List of genes associated with reproductive phenotypes of the database Mouse Genome Informatics (MGI - www.informatics.jax.org) mapping to DEGs. Genes and the corresponding mammalian phenotypes (MP) are indicated

From: Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile

Gene Symbol FC 1st set FC 2nd set Term MP ID
Abca1 −3.2*** −2.8 Male infertility MP:0001925
Female infertility MP:0001926
Abnormal ovary morphology MP:0001126
Abnormal testis morphology MP:0001146
Ctsh −3.1*** −3.4 Reproductive system phenotype MP:0005389
Gdf9 −3.0*** −2.3 Female infertility MP:0001926
Abnormal oogenesis MP:0001931
Abnormal ovarian folliculogenesis MP:0001130
Increased circulating fsh MP:0001750
Increased circulating lh MP:0001751
Agt −2.8*** −2.1 Decreased ovulation rate MP:0003355
Gpr133/Adgrd1 −2.8** −3.0 Female infertility MP:0001926
Eno4 −2.8*** −2.4 Male infertility MP:0001925
Asthenozoospermia MP:0002675
Oligozoospermia MP:0002687
Vcam1 −2.0*** −2.2 Reproductive system phenotype MP:0005389
Pttg1 −1.7*** −1.8 Reduced fertility MP:0001921
Decreased litter size MP:0001935
Decreased testis weight MP:0004852
Hoxa5 −1.6* −1.6 Abnormal estrous cycle MP:0001927
Nr2c2 −1.5** −1.5 Reduced male fertility MP:0001922
Oligozoospermia MP:0002687
Cyp19a1 1.7*** 1.7 Male infertility MP:0001925
Female infertility MP:0001926
Impaired ovarian folliculogenesis MP:0001129
Asthenozoospermia MP:0002675
Oligozoospermia MP:0002687
Leydig cell hyperplasia MP:0001152
Increased circulating fsh MP:0001750
Increased circulating lh MP:0001751
Adamts5 1.8*** 1.7 Reproductive system phenotype MP:0005389
Atxn7 1.8*** 1.8 Male infertility MP:0001925
Female infertility MP:0001926
Clec4a2 2.0*** 1.6 Seminiferous tubule degeneration MP:0001154
Antxr2 2.6** 2.6 Female infertility MP:0001926
Ccnd2 3.1*** 3.0 Abnormal ovulation MP:0001928
Abnormal ovarian folliculogenesis MP:0001130
Oligozoospermia MP:0002687
  1. FC of 1st (*, p < 0 .05; **, p < 0 .01; ***, p < 0 .001) and 2nd microarray set are provided in the table