Table 3 List of genes associated with reproductive phenotypes of the database Mouse Genome Informatics (MGI - www.informatics.jax.org) mapping to DEGs. Genes and the corresponding mammalian phenotypes (MP) are indicated
Gene Symbol | FC 1st set | FC 2nd set | Term | MP ID |
|---|---|---|---|---|
Abca1 | −3.2*** | −2.8 | Male infertility | MP:0001925 |
Female infertility | MP:0001926 | |||
Abnormal ovary morphology | MP:0001126 | |||
Abnormal testis morphology | MP:0001146 | |||
Ctsh | −3.1*** | −3.4 | Reproductive system phenotype | MP:0005389 |
Gdf9 | −3.0*** | −2.3 | Female infertility | MP:0001926 |
Abnormal oogenesis | MP:0001931 | |||
Abnormal ovarian folliculogenesis | MP:0001130 | |||
Increased circulating fsh | MP:0001750 | |||
Increased circulating lh | MP:0001751 | |||
Agt | −2.8*** | −2.1 | Decreased ovulation rate | MP:0003355 |
Gpr133/Adgrd1 | −2.8** | −3.0 | Female infertility | MP:0001926 |
Eno4 | −2.8*** | −2.4 | Male infertility | MP:0001925 |
Asthenozoospermia | MP:0002675 | |||
Oligozoospermia | MP:0002687 | |||
Vcam1 | −2.0*** | −2.2 | Reproductive system phenotype | MP:0005389 |
Pttg1 | −1.7*** | −1.8 | Reduced fertility | MP:0001921 |
Decreased litter size | MP:0001935 | |||
Decreased testis weight | MP:0004852 | |||
Hoxa5 | −1.6* | −1.6 | Abnormal estrous cycle | MP:0001927 |
Nr2c2 | −1.5** | −1.5 | Reduced male fertility | MP:0001922 |
Oligozoospermia | MP:0002687 | |||
Cyp19a1 | 1.7*** | 1.7 | Male infertility | MP:0001925 |
Female infertility | MP:0001926 | |||
Impaired ovarian folliculogenesis | MP:0001129 | |||
Asthenozoospermia | MP:0002675 | |||
Oligozoospermia | MP:0002687 | |||
Leydig cell hyperplasia | MP:0001152 | |||
Increased circulating fsh | MP:0001750 | |||
Increased circulating lh | MP:0001751 | |||
Adamts5 | 1.8*** | 1.7 | Reproductive system phenotype | MP:0005389 |
Atxn7 | 1.8*** | 1.8 | Male infertility | MP:0001925 |
Female infertility | MP:0001926 | |||
Clec4a2 | 2.0*** | 1.6 | Seminiferous tubule degeneration | MP:0001154 |
Antxr2 | 2.6** | 2.6 | Female infertility | MP:0001926 |
Ccnd2 | 3.1*** | 3.0 | Abnormal ovulation | MP:0001928 |
Abnormal ovarian folliculogenesis | MP:0001130 | |||
Oligozoospermia | MP:0002687 |