Skip to main content

Table 4 Gene Ontology (GO) term enrichment analysis for testis of FL2 versus Ctrl line using the platform Database for Annotation, Visualization and Integrated Discovery (DAVID). Functional Annotation Clustering of differentially expressed genes in FL2 versus Ctrl testis. The analysis for the top overrepresented GO terms with fold-enrichment scores and Benjamin’s correction are indicated

From: Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile

Term Genes Fold Enrichment Benjamini
Renin-angiotensin system AGT, KLK1B21, KLK1B8, KLK1B22, KLK1B9, KLK1B11, KLK1B26, KLK1B24, KLK1B1, MAS1 27.5 6 × 10−09
Serine-type endopeptidase activity KLK1B21, KLK1B8, KLK1B22, KLK1B9, KLK1B11, KLK1B26, KLK1B4, KLK1B24, KLK1B1, EGFBP2, KLK1B16, KLK1B27, CTSH 6.7 9 × 10−05
Serine-type endopeptidase inhibitor activity SERPINE3, SERPINA3G, AGT, SERPINA3C, SERPINA3A 4.3 8 × 10−01
Ovarian steroidogenesis CYP1B1, HSD3B6, GDF9, CYP19A1 6.76 6 × 10−01
Steroid hormone biosynthesis CYP1B1, HSD3B6, CYP21A1, CYP19A1 4.43 7 × 10−01
Fatty acid biosynthetic process ELOVL3, AGMO, TECR, OXSM, NDUFS6 5.77 9 × 10−01
Jak-STAT signaling pathway CCND2, SOS1, LIFR, CNTFR, IL3RA 3.32 7 × 10−01
Cyclin-dependent protein serine/threonine kinase activity CDK15, CDK14, CDKL4 9.81 9 × 10−01