Table 4 Gene Ontology (GO) term enrichment analysis for testis of FL2 versus Ctrl line using the platform Database for Annotation, Visualization and Integrated Discovery (DAVID). Functional Annotation Clustering of differentially expressed genes in FL2 versus Ctrl testis. The analysis for the top overrepresented GO terms with fold-enrichment scores and Benjamin’s correction are indicated
Term | Genes | Fold Enrichment | Benjamini |
|---|---|---|---|
Renin-angiotensin system | AGT, KLK1B21, KLK1B8, KLK1B22, KLK1B9, KLK1B11, KLK1B26, KLK1B24, KLK1B1, MAS1 | 27.5 | 6 × 10−09 |
Serine-type endopeptidase activity | KLK1B21, KLK1B8, KLK1B22, KLK1B9, KLK1B11, KLK1B26, KLK1B4, KLK1B24, KLK1B1, EGFBP2, KLK1B16, KLK1B27, CTSH | 6.7 | 9 × 10−05 |
Serine-type endopeptidase inhibitor activity | SERPINE3, SERPINA3G, AGT, SERPINA3C, SERPINA3A | 4.3 | 8 × 10−01 |
Ovarian steroidogenesis | CYP1B1, HSD3B6, GDF9, CYP19A1 | 6.76 | 6 × 10−01 |
Steroid hormone biosynthesis | CYP1B1, HSD3B6, CYP21A1, CYP19A1 | 4.43 | 7 × 10−01 |
Fatty acid biosynthetic process | ELOVL3, AGMO, TECR, OXSM, NDUFS6 | 5.77 | 9 × 10−01 |
Jak-STAT signaling pathway | CCND2, SOS1, LIFR, CNTFR, IL3RA | 3.32 | 7 × 10−01 |
Cyclin-dependent protein serine/threonine kinase activity | CDK15, CDK14, CDKL4 | 9.81 | 9 × 10−01 |