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Fig. 8 | BMC Genomics

Fig. 8

From: Weighted likelihood inference of genomic autozygosity patterns in dense genotype data

Fig. 8

Distribution of differential ROA signals between subgroups in the ITU and PJL. Manhattan plots showing for each window the log 10 (P) of pairwise comparisons of per-individual wLOD scores in the two subgroups present in the (a) ITU (580 SNV window) and (b) PJL (610 SNV window). In each plot, P-values for the comparison testing whether wLOD scores in cluster A are greater than those in cluster B (Additional file 1: Figure S25) are shown on top with P-values for the reverse comparison shown below. P-values represent the proportion of genome-wide maximum Wilcoxon rank-sum test statistics observed in 1000 permutations of group labels that exceed the Wilcoxon rank-sum test statistic obtained with the true labels [152]. Windows with P > 0.05 are shown in black and those with P ≤ 0.05 are shown in orange. The horizontal grey dashed line denotes P = 0.05 and while the grey dotted line denotes P = 0.01

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