Table 3 Enriched functions of DE genes in the Down and Up group using DAVID (89% grain vs. 72% grain)

 GO:0045087~innate immune response

8.2E-05

EIF2AK2, MX1, S100A9, C2, NLRC5, C1QB

 GO:0042742~defense response to bacterium

1.2E-04

ISG15, CXCL5, TAP

 GO:0006958~complement activation, classical pathway

2.7E-04

C3, C2, C1QB

 GO:0051607~defense response to virus

9.8E-04

OAS1Y, ISG15, MX1, NLRC5

 GO:0045071~negative regulation of viral genome replication

1.2E-03

EIF2AK2, ISG15, MX1

 GO:0009636~response to toxic substance

2.4E-03

EIF2QK2, CYP1A1, CYP1B1

 GO:0009404~toxin metabolic process

1.1E-02

CYP1A1, CYP1B1

 GO:2,000,427~positive regulation of apoptotic cell clearance

1.5E-02

C3, C2

 GO:0006956~complement activation

1.8E-02

C3, C2

 GO:0034340~response to type I interferon

2.2E-02

ISG15, MX1

 GO:0006955~immune response

2.2E-02

OAS1Y, CXCL5, LOC504773

 GO:0070098~chemokine-mediated signaling pathway

4.7E-02

CXCL5, LOC504773

 GO:0035914~skeletal muscle cell differentiation

3.2E-02

EGR1, FOS

 GO:0051301~cell division

4.4E-09

SKA3, ASPM, CKS2, PTTG1, CCNB1, BIRC5, CCNB2, AURKA, SPC24, NCAPH, UBE2C, CCNA2, CDCA3, SPDL1, TPX2

 GO:0007080~mitotic metaphase plate congression

6.0E-05

KIF22, KIFC1, CDCA8, KIF2C, CCNB1, SPDL1

 GO:0007018~microtubule-based movement

1.1E-04

KIF22, KIFC1, KIF2C, KIF11, KIF20A, CENPE

 GO:0007059~chromosome segregation

3.1E-04

SKA3, SLC25A5, KIF11, CENPT, BIRC5, HJURP

 GO:0007067~mitotic nuclear division

3.8E-04

PLK1, SKA3, ASPM, CCNA2, PTTG1, CCNB2, NUF2, SPC24

 GO:0031577~spindle checkpoint

6.1E-04

AURKB, BIRC5, SPDL1

 GO:0045143~homologous chromosome segregation

6.1E-04

PLK1, ESPL1, PTTG1

 GO:0000070~mitotic sister chromatid segregation

1.4E-03

PLK1, CDCA8, ESPL1, SPAG5

 GO:0051988~regulation of attachment of spindle microtubules to kinetochore

2.0E-03

RACGAP1, ECT2, SPAG5

 GO:0007052~mitotic spindle organization

2.7E-03

AURKB, CCNB1, NDC80, AURKA

 GO:0000281~mitotic cytokinesis

4.1E-03

PLK1, RACGAP1, KIF20A, CKAP2

 GO:0090307~mitotic spindle assembly

5.3E-03

KIFC1, KIF11, BIRC5, TPX2

 GO:0034501~protein localization to kinetochore

5.4E-03

AURKB, SPDL1, BUB1B

 GO:0010628~positive regulation of gene expression

6.7E-03

MAPK11, CAV1, ACTA2, FN1, ACTG2, VIM

 GO:0000910~cytokinesis

8.0E-03

CIT, KIF20A, BIRC5, ECT2

 GO:0007094~mitotic spindle assembly checkpoint

1.2E-02

PLK1, BUB1B, BUB1

 GO:0071346~cellular response to interferon-gamma

1.9E-02

SLC26A6, GAPDH, LOC504773

 GO:0001578~microtubule bundle formation

2.4E-02

PLK1, KIF20A, TPPP3

 GO:0006096~glycolytic process

2.7E-02

GAPDH, ENO1, ENO2

 GO:0035606~peptidyl-cysteine S-trans-nitrosylation

2.8E-02

GAPDH, S100A9

 GO:0006816~calcium ion transport

3.9E-02

CAV1, ANXA6, CACNA1G

 GO:0045931~positive regulation of mitotic cell cycle

3.9E-02

CCNB1, BIRC5, CDC25B

 GO:0043507~positive regulation of JUN kinase activity

1.4E-02

FZD5, EDN1, EPHA4

 GO:2,001,237~negative regulation of extrinsic apoptotic signaling pathway

2.6E-02

PHIP, ITGAV, TGFBR1

 GO:0009404~toxin metabolic process

2.9E-02

CYP1A1, CYP1B1

 GO:0018406~protein C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan

2.9E-02

DPY19L3, DPY19L4

 GO:0002904~positive regulation of B cell apoptotic process

2.9E-02

FNIP1, CD24

 GO:0042632~cholesterol homeostasis

3.0E-02

CD24, ABCA1, EPHX2

 GO:0017144~drug metabolic process

3.8E-02

CYP1A1, FMO5

 GO:0045944~positive regulation of transcription from RNA polymerase II promoter

4.1E-02

PHIP, TET2, FZD5, EDN1, CCNT1, FOS, NRIP1, MYSM1, PCGF5