Table 4 Differences in functional enrichments between EPA and promoters using Pathway Commons
Cell type | Term of functional annotation | No. of TF EPA (Association rule 4) | No. of TF Promoter | P-value | Experimental support |
|---|---|---|---|---|---|
Monocytes | IFN-gamma pathway | 51 | 10 | 6.89 × 10−4 | [12] |
|  | IL3-mediated signaling events | 46 | 11 | 4.69 × 10−3 | [13] |
|  | GMCSF-mediated signaling events | 43 | 10 | 5.25 × 10−3 | [14] |
|  | PDGF receptor signaling network | 43 | 8 | 1.34 × 10−2 | [15] |
|  | VEGF and VEGFR signaling network | 44 | 9 | 2.10 × 10−3 | [16] |
CD4+ T cell | Integrin family cell surface interactions | 112 | 13 | 2.59 × 10−12 | [17] |
|  | IFN-gamma pathway | 107 | 12 | 5.26 × 10−12 | [18] |
|  | LKB1 signaling events | 107 | 11 | 1.96 × 10−12 | [19] |
|  | TCR signaling in naive CD4+ T cells | 103 | 21 | 3.98 × 10−8 | [20] |
|  | IL3-mediated signaling events | 100 | 8 | 9.54 × 10−13 | [21] |
CD20+ B cell | Integrin family cell surface interactions | 69 | 2 | 5.17 × 10−11 | [22] |
|  | IL5-mediated signaling events | 64 | 0 | 2.21 × 10−11 | [23] |
|  | Insulin Pathway | 63 | 0 | 3.15 × 10−11 | [24] |
|  | mTOR signaling pathway | 63 | 0 | 3.15 × 10−11 | [25] |
|  | Sphingosine 1-phosphate (S1P) pathway | 63 | 0 | 3.15 × 10−11 | [26] |