Table 6 Differences in functional enrichments between EPA shortened at FR CTCF and EPA without CTCF using Pathway Commons
Cell type | Term of functional annotation | No. of TF EPA (Association rule 4) shortened at FR CTCF | No. of TF EPA (Association rule 4) without CTCF | P-value | Experimental support |
|---|---|---|---|---|---|
Monocytes | CXCR4-mediated signaling events | 33 | 14 | 7.81 × 10−12 | [29] |
|  | GPVI-mediated activation cascade | 26 | 3 | 8.97 × 10−15 | [30] |
|  | Signaling events mediated by TCPTP | 23 | 10 | 1.46 × 10−8 | [31] |
|  | p38 MAPK signaling pathway | 16 | 8 | 6.97 × 10−6 | [32] |
|  | IL4-mediated signaling events | 11 | 3 | 8.80 × 10−6 | [33] |
CD4+ T cell | CXCR4-mediated signaling events | 181 | 82 | < 2.20 × 10−16 | [34] |
|  | Fc-epsilon receptor I signaling in mast cells | 85 | 25 | < 2.20 × 10−16 | [35] |
|  | JNK signaling in the CD4+ TCR pathway | 65 | 18 | < 2.20 × 10−16 | [36] |
|  | Reelin signaling pathway | 62 | 26 | < 2.20 × 10−16 | [37] |
|  | Semaphorin interactions | 51 | 14 | < 2.20 × 10−16 | [38] |
CD20+ B cell | Syndecan-4-mediated signaling events | 85 | 40 | < 2.20 × 10−16 | [39] |
|  | CXCR4-mediated signaling events | 77 | 15 | < 2.20 × 10−16 | [40] |
|  | EPO signaling pathway | 46 | 19 | 4.50 × 10−15 | [41] |
|  | Stabilization and expansion of the E-cadherin adherens junction | 32 | 16 | 1.06 × 10−9 | [42] |
|  | Interleukin-1 signaling | 13 | 1 | 3.98 × 10−8 | [43] |