Fig. 4
Conservation Enrichment (CEf) is correlated with functional enrichment. a Genes overlapping HVR subsets. The colour gradient shows the significance obtained from the enrichment analyses done in each of the HVR subsets. Bar sizes indicates the total number of genes overlapping each subset of HVRs. b Liver-genes defined by UP_TISSUE annotation. The functional annotation analyses were calculated by DAVID 6.7. Colour gradient and bar size defined as above. c Rat orthologues of human GWAS regions associated with obesity and metabolic traits. We excluded HVR subsets with CEf > 0.6 and CEf > 0.8 due to no GWAS variants overlapping these HVR subsets. Colour gradient and bar size defined as above. d Ratio of genes differentially expressed in either liver or kidney, between LH and LN strains, and between LL and LN strains (y-axis) for each subset of HVRs. e Proportion of synonymous coding SSV (SC-SSV) and non-synonymous coding SSVs (NSC-SSV) in HVRs for each subset of HVRs. Related Figures: Additional file 1: Figures S4, S5, S7 and S10