Table 1 Top loci identified as transferred from macrophage to adipocyte possibly mediated through macrophage-derived exosomes
Location | Gene Symbol | AD GT a | MO GT | Allele Type b | AD co N1 | AD co N2 | AD co N3 | AD alone Count | FDR | ADMO exosome FPKM d | MO exosome FPKM | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BF c | Count | BF | Count | BF | Count | |||||||||
chr19:10,286,547 | ICAM1 | T/T | C/C | T|C | 4.91E + 03 | 16|2 | 2.68E + 11 | 94|7 | 1.08E + 07 | 44|4 | 37 | 1.96E-06 | 1.89E-01 | 7.29E-01 |
chr2:237,340,987 | COL6A3 | T/T | T/C | T|C|G | 2.03E + 03 | 2450|11|0 | 9.67E + 00 | 2999|8|1 | 6.95E + 03 | 1851|8|2 | 2184|6|1 | 1.07E-03 | 1.58E-02 | 1.13E + 00 |
chr9:116,153,914 | PAPPA | G/G | A/G | G|A|T | 6.51E + 04 | 766|6|0 | 1.99E + 02 | 1963|6|4 | 1.37E + 00 | 1464|3 | 572|1|0 | 2.65E-03 | 9.61E-03 | 1.26E-01 |
chr11:110,127,909 | ZC3H12C | G/G | A/G | G|A | 1.05E + 17 | 4|6 | 1.73E + 11 | 6|4 | NA | NA | 2 | 2.67E-03 | 4.81E-02 | 2.08E-01 |
chr20:58,995,401 | CTSZ | C/C | T/T | C|T | 5.97E-01 | 120|1 | 3.53E + 02 | 392|3 | 5.92E + 02 | 288|3 | 377 | 4.13E-03 | 2.31E-01 | 2.92E-01 |
chr18:23,544,981 | NPC1 | G/G | C/C | G|C|A | 1.81E + 00 | 16|1|0 | 3.66E + 03 | 152|3|1 | 9.73E-01 | 74|1|0 | 49 | 1.29E-02 | 1.19E + 00 | 2.12E + 00 |
chr2:117,918,535 | CCDC93 | C/C | T/T | C|T | 3.57E + 00 | 48|1 | 2.34E + 00 | 53|1 | 8.53E + 00 | 27|1 | 55 | 4.26E-02 | 3.57E-01 | 1.57E + 00 |
chr21:39,177,540 | PSMG1 | C/C | T/T | C|T | 5.60E-01 | 27|1 | 1.30E + 00 | 72|1 | 4.95E + 00 | 36|1 | 86 | 9.33E-02 | 2.08E + 00 | 8.31E + 00 |