Skip to main content

Advertisement

Table 1 Top loci identified as transferred from macrophage to adipocyte possibly mediated through macrophage-derived exosomes

From: A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells

Location Gene Symbol AD GT a MO GT Allele Type b AD co N1 AD co N2 AD co N3 AD alone Count FDR ADMO exosome FPKM d MO exosome FPKM
BF c Count BF Count BF Count
chr19:10,286,547 ICAM1 T/T C/C T|C 4.91E + 03 16|2 2.68E + 11 94|7 1.08E + 07 44|4 37 1.96E-06 1.89E-01 7.29E-01
chr2:237,340,987 COL6A3 T/T T/C T|C|G 2.03E + 03 2450|11|0 9.67E + 00 2999|8|1 6.95E + 03 1851|8|2 2184|6|1 1.07E-03 1.58E-02 1.13E + 00
chr9:116,153,914 PAPPA G/G A/G G|A|T 6.51E + 04 766|6|0 1.99E + 02 1963|6|4 1.37E + 00 1464|3 572|1|0 2.65E-03 9.61E-03 1.26E-01
chr11:110,127,909 ZC3H12C G/G A/G G|A 1.05E + 17 4|6 1.73E + 11 6|4 NA NA 2 2.67E-03 4.81E-02 2.08E-01
chr20:58,995,401 CTSZ C/C T/T C|T 5.97E-01 120|1 3.53E + 02 392|3 5.92E + 02 288|3 377 4.13E-03 2.31E-01 2.92E-01
chr18:23,544,981 NPC1 G/G C/C G|C|A 1.81E + 00 16|1|0 3.66E + 03 152|3|1 9.73E-01 74|1|0 49 1.29E-02 1.19E + 00 2.12E + 00
chr2:117,918,535 CCDC93 C/C T/T C|T 3.57E + 00 48|1 2.34E + 00 53|1 8.53E + 00 27|1 55 4.26E-02 3.57E-01 1.57E + 00
chr21:39,177,540 PSMG1 C/C T/T C|T 5.60E-01 27|1 1.30E + 00 72|1 4.95E + 00 36|1 86 9.33E-02 2.08E + 00 8.31E + 00
  1. aADGT (MOGT) denotes the genotype of adipocyte (macrophage) reported by SNP array
  2. bAlleleType (Count) denotes all alleles (the number of alleles) mapped at the corresponding location by the RNA-seq data on replicated samples
  3. cThe Bayesian factor calculated at the specific locus for the corresponding sample
  4. dThe fpkm of the gene at ADMOexosome as quantified by Cufflinks