Skip to main content

Advertisement

Table 4 Estimate mRNA transfer rates in in vitro co-culture

From: A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells

Direction Rates Simulation Real Co-culture KS distancec
# Locia #Sig Locib Sig Ratio #Loci #Sig Loci Sig Ratio
MO to AD 0.1 83,984 41,999 5.00E-1 80,969 972 1.20E-2 0.535
0.01 73,838 6288 8.52E-2 74,056 841 1.14E-2 0.140
0.001 73,037 513 7.02E-3 73,441 831 1.13E-2 0.047
0.0001 72,958 107 1.47E-3 73,364 853 1.16E-2 0.066
AD to MO 0.1 225,698 61,305 2.72E-1 235,323 1293 5.49E-3 0.320
0.01 215,598 7965 3.69E-2 223,395 1216 5.44E-3 0.058
0.001 214,592 635 2.96E-3 216,059 1174 5.43E-3 0.025
0.0001 214,509 58 2.70E-4 221,935 1202 5.42E-3 0.034
  1. a The number of overall loci checked in 10 simulated (down-sampled real) samples
  2. b The number of overall significant loci (Bayesian factor > = 20) in 10 simulated (down-sampled real) samples
  3. c The KS distance between the Bayesian factor distribution for simulated data and that for real co-culture data as calculated by ks.test in R