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Table 1 Genes with ≥20 fold-change for at least two time points after HgCl2 exposure (n = 25)

From: Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure

Gene ID Gene Name Product Description Hg t10 Hg t30 Hg t60 PMA t10 PMA t30 PMA t60
b1112 bhsA Biofilm, cell surface and signaling defects, YhcN family 1949 563 94 46 21 n.s.
b4458 oxyS OxyS sRNA activates genes that detoxify oxidative damage 1524 1292 150 10 6 n.s.
b4249 bdcA c-di-GMP-binding biofilm dispersal mediator protein 596 79 7 16 2 n.s.
b3686 ibpB Chaperone, heat-inducible protein of HSP20 family 402 124 281 37 211 9
b0812 dps Stress-induced Fe-binding and storage protein 339 52 n.s. 4 2 n.s.
b4248 yjgH Putative reactive intermediate deaminase, UPF0076 family 296 24 3 6 2 n.s.
b0849 grxA Glutaredoxin 1 246 33 n.s. 14 4 n.s.
b1144 ymfJ Function unknown, e14 prophage 185 39 n.s. 3 3 n.s.
b2582 trxC Thioredoxin 2, zinc-binding; Trx2 134 50 7 24 24 n.s.
b1147 ymfL* Function unknown, e14 prophage 95 29 n.s. n.s. 3 n.s.
b1146 croE* Cro-like repressor, e14 prophage 90 40 n.s. n.s. n.s. n.s.
b3687 ibpA Chaperone, heat-inducible protein of HSP20 family 86 19 41 10 28 4
b2531 iscR Transcriptional repressor for isc operon; contains Fe-S cluster 62 48 9 12 18 n.s.
b1148 ymfM* Function unknown, e14 prophage 49 21 n.s. n.s. n.s. n.s.
b4599 yneM function unknown, membrane-associated; regulated by PhoPQ 38 36 n.s. 3 3 n.s.
b2673 nrdH NrdH-redoxin reducing oxidized NrdEF 35 127 21 7 14 n.s.
b4030 psiE Pho regulon, regulated by phoB and cAMP 35 64 17 38 59 n.s.
b1684 sufA Scaffold protein for assembly of iron-sulfur clusters 32 39 5 n.s. 3 n.s.
b1748 astC Succinylornithine transaminase; carbon starvation protein 30 31 25 34 36 n.s.
b4663 azuC Function unknown; membrane-associated 27 25 36 41 49 n.s.
b0484 copA Copper-, silver-translocating P-type ATPase efflux pump 25 20 n.s. 5 n.s. −10
b2674 nrdI Flavodoxin required for NrdEF cluster assembly 21 73 22 4 7 n.s.
b1747 astA* Arginine succinyltransferase, arginine catabolism 10 20 29 9 14 n.s.
b1020 phoH ATP-binding protein, function unknown 8 71 221 61 365 n.s.
b4002 zraP Zn-dependent periplasmic chaperone 3 27 43 n.s. n.s. −3
  1. Table is sorted by Hg at 10 min column. n.s. = not significantly different from unexposed culture and boldface highlights actual values ≥20-fold. Gene names in boldface have a ≥ 20 differential expression response to both Hg and PMA in at least one time point (n = 8). Genes marked with an asterisk (*) had fewer than 11 average read counts for at least 2 time points in the unexposed condition and were operationally defined as being “off” in that condition. Such genes constituted, the lowest 15th percentile of all genes, based on raw read counts normalized across all libraries and across all biological replicates