Fig. 3

Volcano plot of differentially abundant proteins. a: Differentially abundant proteins at E19 compared with E14; (b): differentially abundant proteins at H1 compared with E19. This is a volcano plot of log2 fold-change (x-axis) versus −log10 Q-value (y-axis, representing the probability that the protein is differentially abundant). Q value ≤0.05 and Fold-change ≥1.2 were set as the significance threshold for differential abundance. The red and green dots indicate points-of-interest that display both large-magnitude fold-changes as well as high statistical significance. Dots in red mean significantly upregulated proteins that passed screening threshold. Dots in green mean significant downregulated proteins that passed screening threshold. Gray dots are non-significant differentially abundant protein