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Table 2 Significant networks with intolerant SNPs from the layer and broiler lines combined

From: Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines

Moleculesa Total no of molecules Score Top diseases and functions
AGAP3, APOLD1, CALCR, CDKL1, EDIL3, FHL5, LEPR, LEPROT, NCOR2, TGFBR1 33 38 connective tissue disorders, metabolic disease, cellular assembly and organization
AMOTL2, API5, BICD1, DZIP1, ERK, FBF1, HEATR1, IFT122, NIN, TEX11 34 35 cellular assembly, organization, morphology and maintenance
GALR3, GPR6, GPR20, GPR26, GPR97, GPR98, LPHN3, LYST, MC2R, MC3R 34 35 cell signalling and interaction, cellular function and maintenance
ABTB1, BRI3BP, CHD9, DDX18, DDX31, ESR1, FKBP7, GREB1, PPIL4, WHSC1 32 33 organismal, embryonic and tissue development
ACTR10, ANK2, APC2, DCTN4, DISC1, DNAH1, DNAH3, DNAH5, FARSB, KIF3C 32 33 cellular assembly and organization, nervous system development, cancer
ACTA2, DSC2, DSG2, DTX1, DTX3L, MTCL1, NOTCH2, SERPINB12, SRC, TMCO4 33 33 cardiac arrhythmia, cardiovascular disease and congenital heart anomaly
AK7, AK8, AK9, ARC, CAPN6, CAPN8, CAPN9, HIP1, KNTC1, PIPOX 30 33 nucleic acid and carbohydrate metabolism
AP5Z1, ASTE1, FLT3, FOXK2, HSP, HSPA2, HSPH1, METAP1, TSC1, PHF3 32 31 cell cycle, developmental and hereditary disorders
  1. aExample of ten molecules present in each network