Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines

Table 2 Significant networks with intolerant SNPs from the layer and broiler lines combined

Molecules^a	Total no of molecules	Score	Top diseases and functions
AGAP3, APOLD1, CALCR, CDKL1, EDIL3, FHL5, LEPR, LEPROT, NCOR2, TGFBR1	33	38	connective tissue disorders, metabolic disease, cellular assembly and organization
AMOTL2, API5, BICD1, DZIP1, ERK, FBF1, HEATR1, IFT122, NIN, TEX11	34	35	cellular assembly, organization, morphology and maintenance
GALR3, GPR6, GPR20, GPR26, GPR97, GPR98, LPHN3, LYST, MC2R, MC3R	34	35	cell signalling and interaction, cellular function and maintenance
ABTB1, BRI3BP, CHD9, DDX18, DDX31, ESR1, FKBP7, GREB1, PPIL4, WHSC1	32	33	organismal, embryonic and tissue development
ACTR10, ANK2, APC2, DCTN4, DISC1, DNAH1, DNAH3, DNAH5, FARSB, KIF3C	32	33	cellular assembly and organization, nervous system development, cancer
ACTA2, DSC2, DSG2, DTX1, DTX3L, MTCL1, NOTCH2, SERPINB12, SRC, TMCO4	33	33	cardiac arrhythmia, cardiovascular disease and congenital heart anomaly
AK7, AK8, AK9, ARC, CAPN6, CAPN8, CAPN9, HIP1, KNTC1, PIPOX	30	33	nucleic acid and carbohydrate metabolism
AP5Z1, ASTE1, FLT3, FOXK2, HSP, HSPA2, HSPH1, METAP1, TSC1, PHF3	32	31	cell cycle, developmental and hereditary disorders

ISSN: 1471-2164