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Table 1 Comparison of features of different tools for massive parallel sequencing annotation and interpretation

From: VAReporter: variant reporter for cancer research of massive parallel sequencing

Tool VARepoter Vanno [61] Annotate-it [55] ANNOVAR [10] Anntools [62] KGGSeq [63] SeqAnt [64] TREAT [65] Oncotator [33]
Availability Web Web Web Command line Command line Command line Web Command line Both
Tracking mislabeled specimen         
SNPs/1000Genomes/COSMIC
Indels  
Cross-sample comparison        
Filters      
Domain information        
Dynamic summarized chart        
Gene Ontology      
Mutational Landscape         
OMIM       
Pathway visualization       
dbNSFP       
Sequence retrieval        
ICGC/TCGA comparison         TCGA only