Fig. 4

SNP in pre-miRNA and its link with diseases. a SNP density in human pre-miRNAs and their flanking regions. Blue (green) bars correspond to human non-mirtrons (mirtrons). The results are based on miRNASNP-2.0 (miRBase 19.0 and dbSNP137) [58]. Red bars were calculated by [73] using miRBase-16.0 and dbSNP132 (miRNASNP-1.0 database). Yellow bars were calculated by [74] using miRBase 18.0 and dbSNP135 (MirSNP database). SNP density is shown separately for seed region, miRNA (without seed region), pre-miRNA (without miRNA) and upstream and downstream pre-miRNA flanks. Note, that the MirSNP data (yellow bars) provide the densities of slightly different regions, namely, the entire pre-miRNA sequence and both 200 bp pre-miRNA flanks. b SNP occurrence per pre-miRNA for disease or non-disease mirtrons and non-mirtrons. The disease pre-miRNAs are associated with at least one disease and were taken from [59, 60], SNPs were extracted from miRNASNP-2.0 [58]