Fig. 1

The result produced by SNP_TATA_Comparator [53] for reproductive potential-related SNP markers in the human ESR2 gene. Legend: a Unannotated SNPs (analyzed in this study) in the region [-70; -20] (where all proven TBP-binding sites (boxed) are located; double-headed arrow, ↔) of the human ESR2 gene promoter retrieved from dbSNP, rel. 147 [6] using the UCSC Genome Browser [12]. Dash-and-double-dot arrows: known and candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TBP for the human ESR2 gene promoter. b and c The results from our Web service SNP_TATA_Comparator [53] for the two SNP markers of reproductive potential: known marker rs35036378 [61] and candidate marker rs766797386 near the known TBP-binding site (boxed) of the human ESR2 gene promoter. Solid, dotted, and dashed arrows indicate queries in the reference human genome [10] by means of the BioPerl library [265]. Dash-and-dot arrows: estimates of significance of the alteration of gene product abundance in patients carrying the minor allele (mut) relative to the norm (ancestral allele, wt) expressed as a Z-score using package R [266]. Circles indicate the ancestral (wt) and minor (mut) alleles of the SNP marker labeled by its dbSNP ID [6]