Fig. 4

Cell culture verification of the selected candidate SNP marker rs28399433 in cell line hTERT-BJ1 (human fibroblasts) transfected with the pGL 4.10 vector carrying a reporter LUC gene. Legend: Dark gray bar, the original vector pGL 4.10 (Promega, USA) without any insertions, which served as an independent control; open bars, ancestral allele (wild type, WT); light gray bar, minor allele (rs28399433). The height of the bars and their error bars correspond to the mean estimates and boundaries of their 95% confidence intervals calculated from five independent experiments. All differences are statistically significant at the confidence level of α < 0.05