Gene | dbSNP [6] rel. 147 or see [Ref] | 5′ flank | wt mut | 3′ flank | KD, nM | Known diseases (SNP markers) or hypothetical disease (candidate SNP markers) | [Ref] or [this work] | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
wt mut | Δ | Z | α | ρ | |||||||
HBB | rs397509430 | gggctgggca | t - | atacaacagt | 5 29 | ↓ | 34 | 10-6 | A | malaria resistance and thalassemia | [176] |
rs33980857 | gggctgggca | t a,g,c | atacaacagt | 5 21 | ↓ | 27 | 10-6 | A | |||
rs34598529 | ggctgggcat | a g | aaagtcaggg | 5 18 | ↓ | 24 | 10-6 | A | |||
rs33931746 | gctgggcata | a g,c | aagtcagggc | 5 11 | ↓ | 14 | 10-6 | A | |||
rs33981098 | agggctgggc | a g,c | taaaagtcag | 5 9 | ↓ | 10 | 10-6 | A | |||
rs34500389 | cagggctggg | c a,t,g | ataaaagtca | 5 6 | ↓ | 3 | 10-2 | C | |||
(hypothetically) the same disease; heterozygotes “wt-mut” are still more viable according to most of clinical indicators in comparison with both homozygotes “wt-wt” and “mut-mut” | [this work], [185] | ||||||||||
rs63750953 | ctgggcataa | aa - | gtcagggcag | 5 8 | ↓ | 9 | 10 -6 | A | |||
rs281864525 | tgggcataaa | a c | gtcagggcag | 5 7 | ↓ | 7 | 10 -6 | A | |||
rs117785782 | ggctgagggt | t c | tgaagtccaa | 28 39 | ↓ | 7 | 10 -6 | A | |||
HBD | rs35518301 | caggaccagc | a g | taaaaggcag | 4 8 | ↓ | 11 | 10-6 | A | malaria resistance and thalassemia | [176] |
(hypothetically) the same disease; heterozygotes “wt-mut” are still more viable according to most of clinical indicators | [this work], [185] | ||||||||||
rs34166473 | aggaccagca | t c | aaaaggcagg | 4 8 | ↓ | 18 | 10 -6 | A | |||
HBG2 | rs745580140 | ggagttgctc | ta - | cacaagctct | 11 22 | ↓ | 10 | 10 -6 | A | ||
ACKR1 | rs2814778 | ttggctctta | t c | cttggaagca | 10 12 | ↓ | 4 | 10-3 | B | low white-blood-cell count and resistance to malaria, (hypothetically) pre-eclampsia | |
MBL2 | rs72661131 | tctatttcta | t c | atagcctgca | 2 4 | ↓ | 12 | 10-6 | A | variable immunedefici-ency, pre-eclampsia, stroke, | |
(hypothetically) the same disease; higher risks of recurrent vulvovaginal infections | [this work], [187] | ||||||||||
rs562962093 | atctatttct | a g | tatagcctgc | 2 5 | ↓ | 15 | 10-6 | A | |||
rs567653539 | tttctatata | g a | cctgcaccca | 2 1 | ↑ | 12 | 10-6 | A | (hypothetically) reduced risks of recurrent vulvovaginal infections | ||
MMP12 | rs2276109 | gatatcaact | a g | tgagtcactc | 11 14 | ↓ | 3 | 10-2 | C | lower risk of psoriasis, systemic sclerosis, asthma | |
(hypothetically), higher risk of ovarian hyper-stimulation syndrome | [this work], [188] | ||||||||||
rs572527200 | gatgatatca | a g | ctatgagtca | 11 14 | ↓ | 3 | 10-2 | C | |||
F2 | rs564528021 | agttcaacat | t c | aacccagagg | 13 9 | ↑ | 7 | 10-6 | A | (hypothetically) high risk of pre-eclampsia | [this work], [189] |
rs752364393 | caacattaac | c t | cagaggggtc | 13 11 | ↑ | 3 | 10-3 | B |