Fig. 4

Chromatin openness state captured by SALP-seq with different numbers of HepG2 cells. a Reads density of different numbers of cells in whole genome scale. b UCSC browser track showing some typical open chromatin regions identified with different numbers of cells by SALP-seq. The chromatin openness state identified by ENCODE was also shown to compare. c Peaks obtained with different numbers of cells. The overlapped peaks were shown. d Fold enrichment of peak obtained with different numbers of cells. e Comparison of overlapped peaks enriched by the SALP-seq reads of 10⁵ and 5 × 10⁴ HepG2 cells. The peaks were called with the same numbers of randomly sampled reads (10⁷) of two cell samples. f Comparison of fold enrichment of different SALP-seq peaks of HepG2 cells. Overlap: peaks overlapped between 10⁵ and 5 × 10⁴ HepG2 cells; Not overlap: peaks not overlapped between 10⁵ and 5 × 10⁴ HepG2 cells